ArticleBMC nephrology2013
The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome.
Article in BMC nephrology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01605266 (INSIGHT), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INSIGHT (Insight Into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics)
Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Steroid-sparing drugs in children and young adults with nephrotic syndrome: a target trial emulation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Trial
- Impact of childhood and parental smoking and substance use on nephrotic syndrome outcomes: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Hypogammaglobulinemia and B cell repopulation after rituximab in childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Machine learning prediction of childhood nephrotic syndrome outcomes.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Mental health among caregivers of children with nephrotic syndrome: a prospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Associations Between Toxic Metal Exposure and Childhood Nephrotic Syndrome.Kidney international reports · 2026Article
- Establishing core outcomes and minimal clinically important differences for childhood steroid sensitive nephrotic syndrome clinical trials: results from a Delphi consensus process.Pediatric nephrology (Berlin, Germany) · 2026Article
- Aligning Practice With Guidelines: A Canadian National Survey and Canadian Society of Nephrology Commentary on the 2025 KDIGO Pediatric Nephrotic Syndrome Recommendations.Canadian journal of kidney health and disease · 2026Article
- Effect of laparoscopic sleeve gastrectomy on heart remodeling and right ventricular function.Caspian journal of internal medicine · 2026Article
- Challenging Clinical Practice Guideline Definitions in Childhood Nephrotic Syndrome.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- A "Trial within a Cohort" platform for pediatric clinical trials on idiopathic nephrotic syndrome: scope, objectives, and design of the retrospective-prospective cohort PIN'SNP.Pediatric nephrology (Berlin, Germany) · 2025Article
- Prolonged remission after cyclophosphamide or tacrolimus treatment in childhood nephrotic syndrome: a cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Incidence and Pathological Patterns of Nephrotic Syndrome among Infants and Children: A Systematic Review.Cureus · 2024Review
- Family functioning and quality of life among children with nephrotic syndrome during the first pandemic wave.Pediatric nephrology (Berlin, Germany) · 2023Article
- Common Risk Variants inKidney international reports · 2023Article
- Shared genetic risk across different presentations of gene test-negative idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2023Article
- Relationship betweenCaspian journal of internal medicine · 2023Article
- Evaluation ofMedical journal of the Islamic Republic of Iran · 2021Article
- Article
- Impact of steroids and steroid-sparing agents on quality of life in children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNephrotic syndrome is one of the most commonly diagnosed kidney diseases in childhood and its progressive forms can lead to chronic kidney disease (CKD) and/or end-stage renal disease (ESRD). There have been few longitudinal studies among a multi-ethnic cohort to determine potential risk factors influencing disease susceptibility, treatment response, and progression of nephrotic syndrome. Temporal relationships cannot be studied through cross-sectional study design. Understanding the interaction between various factors is critical to developing new strategies for treating children with kidney disease. We present the rationale and the study design of a longitudinal cohort study of children with nephrotic syndrome, the Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT) study. The specific aims are to determine: 1) socio-demographic, environmental, and genetic factors that influence disease susceptibility; 2) rates of steroid treatment resistance and steroid treatment dependence, and identify factors that may modify treatment response; 3) clinical and genetic factors that influence disease susceptibility and progression to CKD and ESRD; and 4) the interaction between the course of illness and socio-demographic, environmental, and clinical risk factors. METHODS/
designINSIGHT is a disease-based observational longitudinal cohort study of children with nephrotic syndrome. At baseline, participants complete questionnaires and provide biological specimen samples (blood, urine, and toenail clippings). Follow-up questionnaires and repeat biological specimen collections are performed annually for up to five years. DISCUSSION: The proposed cohort will provide the structure to test various risk factors predicting or influencing disease susceptibility, treatment response, and progression to CKD among children with nephrotic syndrome.
trial registrationClinicalTrials.gov Identifier NCT01605266.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.