ArticleMediterranean journal of hematology and infectious diseases2013
Beta thalassemia major in a developing country: epidemiological, clinical and evolutionary aspects.
Article in Mediterranean journal of hematology and infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The epidemiology of hepatitis C virus in the Maghreb region: systematic review and meta-analyses.PloS one · 2015Pooled it
- Genomewide DNA Methylation Responses in Patients with β-Thalassemia Treated with Yisui Shengxue Granules ().Chinese journal of integrative medicine · 2019Trial
- Mutation Spectrum of Hemoglobinopathies in Tunisia.Human mutation · 2026Article
- Epidemiology of the Incidence, Prevalence, and Mortality of Thalassemia in Iran: A Secondary Analysis of Global Burden of Disease 2019.Health science reports · 2025Article
- High Serum Ferritin Levels among Blood Transfused Thalassemic Patients Admitted to the Department of Paediatrics in a Tertiary Care Centre: A Descriptive Cross-Sectional Study.JNMA; journal of the Nepal Medical Association · 2023Article
- A cross-sectional study of awareness and practices regarding thalassemia among parents of thalassemic children.Journal of family medicine and primary care · 2020Article
- Alpha-Thalassemia in North Morocco: Prevalence and Molecular Spectrum.BioMed research international · 2019Article
- Growth and Endocrine Function in Tunisian Thalassemia Major Patients.Mediterranean journal of hematology and infectious diseases · 2018Article
- Ischemia-modified albumin as a marker of vascular dysfunction and subclinical atherosclerosis in β-thalassemia major.Redox report : communications in free radical research · 2017Article
- Survival analysis and its associated factors of Beta thalassemia major in hamadan province.Iranian journal of medical sciences · 2015Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beta-thalassemia major (TM) remains to be one of the major health problems particularly in developing countries. Tunisia is a part of the Mediterranean countries mostly affected by this disease which is highly concentrated in small towns in families with low-income earners. The main objectives of this study are to provide a description of the demographic, clinical features and transfusion-related complications in patients with TM living in Tunisia. A standardized questionnaire was sent to clinicians throughout 33 different medical institutions caring for thalassemic patients. 391 transfusion dependant thalassemic patients with a median age of 10.7 years (range 3 months- 31 years) were included in the study. The majority originated from the north west of the country. A moderate iron overload between 1501 and 2500 ng/ml was found in 61patients, while 81 patients (26.9%) had a ferritin level more than 2500 ng/ml and greater than 5000ng/ml in 21 patients (6.9%). 51 patients died from complications related to their disease. Heart failure was the main cause of death. The incidence of cardiac, endocrine, and infectious complications will be reviewed. Preventive measures such as health education, carrier screening and premarital screening remain the best ways for lowering the incidence of these diseases, which might be reflected in financial saving, social s and health benefits.
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Registered trials
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