ArticlePloS one2013
Effect of maternal lipopolysaccharide administration on the development of dopaminergic receptors and transporter in the rat offspring.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Effects of combined prenatal exposure to air pollution and maternal stress on immune and dopaminergic gene expression in the gut-brain axis.Brain, behavior, & immunity - health · 2026Article
- Lipopolysaccharide Effects on Neurotransmission: Understanding Implications for Depression.ACS chemical neuroscience · 2024Review
- Animal Models of Relevance to the Schizophrenia Prodrome.Biological psychiatry global open science · 2023Review
- Protective Effects of Interleukin-1 Blockade on Group BFrontiers in endocrinology · 2022Article
- An Shen Ding Zhi Ling Alleviates Symptoms of Attention Deficit Hyperactivity Disorder via Anti-Inflammatory Effects in Spontaneous Hypertensive Rats.Frontiers in pharmacology · 2020Article
- Neuroinflammation as a risk factor for attention deficit hyperactivity disorder.Pharmacology, biochemistry, and behavior · 2019Review
- Brain changes in a maternal immune activation model of neurodevelopmental brain disorders.Progress in neurobiology · 2019Review
- N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges.Psychopharmacology · 2018Article
- Intrauterine inflammation induces sex-specific effects on neuroinflammation, white matter, and behavior.Brain, behavior, and immunity · 2017Article
- Primary Pediatric Hypertension: Current Understanding and Emerging Concepts.Current hypertension reports · 2017Review
- Maternal Immune Activation Disrupts Dopamine System in the Offspring.The international journal of neuropsychopharmacology · 2016Article
- Abnormal context-reward associations in an immune-mediated neurodevelopmental mouse model with relevance to schizophrenia.Translational psychiatry · 2015Article
- Inflammation During Gestation Induced Spatial Memory and Learning Deficits: Attenuated by Physical Exercise in Juvenile Rats.Journal of clinical and diagnostic research : JCDR · 2015Article
- Brain in flames - animal models of psychosis: utility and limitations.Neuropsychiatric disease and treatment · 2015Review
- Prenatal lipopolysaccharide exposure results in dysfunction of the renal dopamine D1 receptor in offspring.Free radical biology & medicine · 2014Article
- Prenatal stress-induced increases in placental inflammation and offspring hyperactivity are male-specific and ameliorated by maternal antiinflammatory treatment.Endocrinology · 2014Article
- Inflammation and the two-hit hypothesis of schizophrenia.Neuroscience and biobehavioral reviews · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Epidemiological evidence supports that maternal infection during gestation are notable risk factors for developmental mental illnesses including schizophrenia and autism. In prenatal lipopolysaccharide (LPS) model of immune activation in rats, the offspring exhibit significant impairments in behaviors mediated by central dopamine (DA) system. This study aimed to examine the temporal and regional pattern of postnatal DA development in the male offspring of pregnant Sprague-Dawley rats administered with 100 µg/kg LPS or saline at gestational days 15/16. Using ligand autoradiography, D1 and D2 dopamine receptors (D1R, D2R) and dopamine transporter (DAT) binding levels were measured in the prefrontal cortex (PFC) and sub cortical regions (dorsal striatum and nucleus accumbens core and shell) at pre pubertal (P35) and post pubertal ages (P60). We found a significant decrease in D2R ligand [(3)H] YM-90151-2 binding in the medial PFC (mPFC) in prenatal LPS-treated animals at P35 and P60 compared to respective saline groups. The decrease in D2R levels was not observed in the striatum or accumbens of maternal LPS-treated animals. No significant changes were observed in [(3)H] SCH23390 binding to D1R. However, the level of [(125)I] RTI-121 binding to DAT was selectively reduced in the nucleus accumbens core and shell at P35 in the prenatal LPS group. Immunohistochemical analysis showed that number of D2R immunopositive cells in infralimbic/prelimbic (IL/PL) part of mPFC was significantly reduced in the LPS group at P60. Prenatal LPS treatment did not significantly affect either the total number of mature neurons or parvalbumin (PV)-immunopositive interneurons in this region. However the number of PV and D2R co-labeled neurons was significantly reduced in the IL/PL subregion of PFC of LPS treated animals. Our data suggests D2R deficit in the PFC and PV interneurons may be relevant to understanding mechanisms of cortical dysfunctions described in prenatal infection animal models as well as schizophrenia.
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