ArticlePloS one2013
Passive exercise of the hind limbs after complete thoracic transection of the spinal cord promotes cortical reorganization.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Neural Stimulation and Molecular Mechanisms of Plasticity and Regeneration: A Review.Frontiers in cellular neuroscience · 2020Pooled it
- Review
- Influence of sports on cortical excitability in patients with spinal cord injury: a TMS study.Frontiers in medical technology · 2024Article
- An electroencephalography-based human-machine interface combined with contralateral C7 transfer in the treatment of brachial plexus injury.Neural regeneration research · 2022Review
- Effect of Acute Physical Interventions on Pathophysiology and Recovery After Spinal Cord Injury: A Comprehensive Review of the Literature.Neurospine · 2022Article
- When Spinal Neuromodulation Meets Sensorimotor Rehabilitation: Lessons Learned From Animal Models to Regain Manual Dexterity After a Spinal Cord Injury.Frontiers in rehabilitation sciences · 2021Review
- Reorganization of Higher-Order Somatosensory Cortex After Sensory Loss from Hand in Squirrel Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Differences in neuroplasticity after spinal cord injury in varying animal models and humans.Neural regeneration research · 2019Review
- A rodent brain-machine interface paradigm to study the impact of paraplegia on BMI performance.Journal of neuroscience methods · 2018Article
- Serotonin receptor and dendritic plasticity in the spinal cord mediated by chronic serotonergic pharmacotherapy combined with exercise following complete SCI in the adult rat.Experimental neurology · 2018Article
- Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats.eLife · 2017Article
- Exercise and Peripheral Nerve Grafts as a Strategy To Promote Regeneration after Acute or Chronic Spinal Cord Injury.Journal of neurotrauma · 2017Review
- Passive cycling in neurorehabilitation after spinal cord injury: A review.The journal of spinal cord medicine · 2017Review
- Teaching Adult Rats Spinalized as Neonates to Walk Using Trunk Robotic Rehabilitation: Elements of Success, Failure, and Dependence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Interactive Effects Between Exercise and Serotonergic Pharmacotherapy on Cortical Reorganization After Spinal Cord Injury.Neurorehabilitation and neural repair · 2016Article
- Exercise Training Promotes Functional Recovery after Spinal Cord Injury.Neural plasticity · 2016Review
- Trunk robot rehabilitation training with active stepping reorganizes and enriches trunk motor cortex representations in spinal transected rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cortical reorganization after spinal cord injury: always for good?Neuroscience · 2014Review
- Dissociating movement from movement timing in the rat primary motor cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Plasticity and alterations of trunk motor cortex following spinal cord injury and non-stepping robot and treadmill training.Experimental neurology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Physical exercise promotes neural plasticity in the brain of healthy subjects and modulates pathophysiological neural plasticity after sensorimotor loss, but the mechanisms of this action are not fully understood. After spinal cord injury, cortical reorganization can be maximized by exercising the non-affected body or the residual functions of the affected body. However, exercise per se also produces systemic changes - such as increased cardiovascular fitness, improved circulation and neuroendocrine changes - that have a great impact on brain function and plasticity. It is therefore possible that passive exercise therapies typically applied below the level of the lesion in patients with spinal cord injury could put the brain in a more plastic state and promote cortical reorganization. To directly test this hypothesis, we applied passive hindlimb bike exercise after complete thoracic transection of the spinal cord in adult rats. Using western blot analysis, we found that the level of proteins associated with plasticity - specifically ADCY1 and BDNF - increased in the somatosensory cortex of transected animals that received passive bike exercise compared to transected animals that received sham exercise. Using electrophysiological techniques, we then verified that neurons in the deafferented hindlimb cortex increased their responsiveness to tactile stimuli delivered to the forelimb in transected animals that received passive bike exercise compared to transected animals that received sham exercise. Passive exercise below the level of the lesion, therefore, promotes cortical reorganization after spinal cord injury, uncovering a brain-body interaction that does not rely on intact sensorimotor pathways connecting the exercised body parts and the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.