ArticlePloS one2013
Casein kinase 1δ activity: a key element in the zebrafish circadian timing system.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Convergent latitudinal erosion of circadian systems in a rapidly diversifying order of fishes.PLoS genetics · 2026Article
- Light-regulated microRNAs shape dynamic gene expression in the zebrafish circadian clock.PLoS genetics · 2025Article
- Two light sensors decode moonlight versus sunlight to adjust a plastic circadian/circalunidian clock to moon phase.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System.International journal of molecular sciences · 2022Article
- A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes.eLife · 2021Article
- Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch.eLife · 2020Article
- Review
- Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen.Scientific reports · 2019Article
- Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights.Medicinal research reviews · 2018Review
- Article
- The innate immune cell response to bacterial infection in larval zebrafish is light-regulated.Scientific reports · 2017Article
- Life in a dark biosphere: a review of circadian physiology in "arrhythmic" environments.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Review
- Article
- Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis.Scientific reports · 2015Article
- Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth.The Journal of cell biology · 2015Article
- The zebrafish period2 protein positively regulates the circadian clock through mediation of retinoic acid receptor (RAR)-related orphan receptor α (Rorα).The Journal of biological chemistry · 2015Article
- Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms.Molecular and cellular biochemistry · 2015Article
- Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.PLoS genetics · 2014Article
- The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light.Nucleic acids research · 2014Article
- The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.Frontiers in oncology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish have become a popular model for studies of the circadian timing mechanism. Taking advantage of its rapid development of a functional circadian clock and the availability of light-entrainable clock-containing cell lines, much knowledge has been gained about the circadian clock system in this species. However, the post-translational modifications of clock proteins, and in particular the phosphorylation of PER proteins by Casein kinase I delta and epsilon (CK1δ and CK1ε), have so far not been examined in the zebrafish. Using pharmacological inhibitors for CK1δ and CK1ε, a pan-CK1δ/ε inhibitor PF-670462, and a CK1ε -selective inhibitor PF-4800567, we show that CK1δ activity is crucial for the functioning of the circadian timing mechanism of zebrafish, while CK1ε plays a minor role. The CK1δ/ε inhibitor disrupted circadian rhythms of promoter activity in the circadian clock-containing zebrafish cell line, PAC-2, while the CK1ε inhibitor had no effect. Zebrafish larvae that were exposed to the CK1δ/ε inhibitor showed no rhythms of locomotor activity while the CK1ε inhibitor had only a minor effect on locomotor activity. Moreover, the addition of the CK1δ/ε inhibitor disrupted rhythms of aanat2 mRNA expression in the pineal gland. The pineal gland is considered to act as a central clock organ in fish, delivering a rhythmic hormonal signal, melatonin, which is regulated by AANAT2 enzymatic activity. Therefore, CK1δ plays a key role in the circadian timing system of the zebrafish. Furthermore, the effect of CK1δ inhibition on rhythmic locomotor activity may reflect its effect on the function of the central clock in the pineal gland as well as its regulation of peripheral clocks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.