ArticlePLoS genetics2013
Genome-wide analysis reveals selection for important traits in domestic horse breeds.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 1 of them a synthesis that pooled it.
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Who cites it
126 citing papers in PubMed, 1 synthesis or guideline pooled it, 275 citations in OpenAlex.
- Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses.Genes · 2019Pooled it
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- Mitochondrial Adaptations to Exercise Training in Equine Skeletal Muscle: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Research Trends and Emerging Frontiers in Racehorse Genetics: A Bibliometric Analysis.Animals : an open access journal from MDPI · 2026Article
- Causal variants in animal genomes: approaches to identification, phenotypic impact, and implications for selective breeding.BMC genomics · 2026Review
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- Heritability Estimates of Traits Assessed in Field Performance Tests of Polish Warmblood Mares.Genes · 2026Article
- Haplotype GWAS in Swedish warmblood horses for conformation and jumping traits.Journal of animal science · 2026Article
- Temporal and intra-horse consistency of circulating myostatin concentrations in Thoroughbred racehorses.Scientific reports · 2025Article
- High-quality, haplotype-resolved reference genomes of the Dutch warmblood horse and Friesian horse using trio binning.BMC genomics · 2025Article
- Integrated multi-omics analysis and functional validation uncovers RPL26 roles in regulating growth traits of Asian water buffaloes (Bubalus bubalis).BMC genomics · 2025Article
- Domestic Quarter Horse (Animals : an open access journal from MDPI · 2025Article
- The Effect of Selection on the Two Important Myostatin Gene Mutations in the Dareshouri Horse in the Middle East.Veterinary medicine and science · 2025Article
- Article
- Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed.International journal of molecular sciences · 2024Article
- A genome-wide association study of the racing performance traits in Yili horses based on Blink and FarmCPU models.Scientific reports · 2024Article
- Genetic diversity and signatures of selection in Icelandic horses and Exmoor ponies.BMC genomics · 2024Article
- An endothelial regulatory module links blood pressure regulation with elite athletic performance.PLoS genetics · 2024Article
- Predicted genetic burden and frequency of phenotype-associated variants in the horse.Scientific reports · 2024Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 20 institutions in 14 countries.
Funding
Abstract
Intense selective pressures applied over short evolutionary time have resulted in homogeneity within, but substantial variation among, horse breeds. Utilizing this population structure, 744 individuals from 33 breeds, and a 54,000 SNP genotyping array, breed-specific targets of selection were identified using an F(ST)-based statistic calculated in 500-kb windows across the genome. A 5.5-Mb region of ECA18, in which the myostatin (MSTN) gene was centered, contained the highest signature of selection in both the Paint and Quarter Horse. Gene sequencing and histological analysis of gluteal muscle biopsies showed a promoter variant and intronic SNP of MSTN were each significantly associated with higher Type 2B and lower Type 1 muscle fiber proportions in the Quarter Horse, demonstrating a functional consequence of selection at this locus. Signatures of selection on ECA23 in all gaited breeds in the sample led to the identification of a shared, 186-kb haplotype including two doublesex related mab transcription factor genes (DMRT2 and 3). The recent identification of a DMRT3 mutation within this haplotype, which appears necessary for the ability to perform alternative gaits, provides further evidence for selection at this locus. Finally, putative loci for the determination of size were identified in the draft breeds and the Miniature horse on ECA11, as well as when signatures of selection surrounding candidate genes at other loci were examined. This work provides further evidence of the importance of MSTN in racing breeds, provides strong evidence for selection upon gait and size, and illustrates the potential for population-based techniques to find genomic regions driving important phenotypes in the modern horse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.