SynthesisJournal of medical genetics2013
Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.
Synthesis in Journal of medical genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Zfp462 Is a Key Mediator of Osteoblast Differentiation and Might Contribute to Age-Related Bone Loss.Aging cell · 2026Article
- Global impact of micronutrients in modern human evolution.American journal of human genetics · 2025Article
- Evaluating the association between placenta DNA methylation and cognitive functions in the offspring.Translational psychiatry · 2024Article
- Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications.Bone research · 2021Review
- Comprehensive Genetic Analysis of 128 Candidate Genes in a Cohort With Idiopathic, Severe, or Familial Osteoporosis.Journal of the Endocrine Society · 2020Article
- Analyzing Genome-Wide Association Study Dataset Highlights Immune Pathways in Lip Bone Mineral Density.Frontiers in genetics · 2020Article
- Recent Advances in the Genetics of Fractures in Osteoporosis.Frontiers in endocrinology · 2019Review
- An Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation.American journal of human genetics · 2018Article
- Using GWAS to identify novel therapeutic targets for osteoporosis.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Targeted Sequencing of Lung Function Loci in Chronic Obstructive Pulmonary Disease Cases and Controls.PloS one · 2017Article
- A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women.Bone reports · 2016Article
- Genetics of osteoporosis: searching for candidate genes for bone fragility.Archives of endocrinology and metabolism · 2016Review
- Value of rare low bone mass diseases for osteoporosis genetics.BoneKEy reports · 2016Review
- Infant sex-specific placental cadmium and DNA methylation associations.Environmental research · 2015Article
- Genetics of ossification of the posterior longitudinal ligament of the spine: a mini review.Journal of bone metabolism · 2014Review
- Genome-wide Association Studies for Osteoporosis: A 2013 Update.Journal of bone metabolism · 2014Review
- Article
Corrections and comments
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Authors and funding
32 authors at 11 institutions in 5 countries.
Funding
Abstract
backgroundOsteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population.
methodsAssociation was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard errors estimated for each study.
resultsIn a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene) that showed genome-wide significance (p=3.59×10(-8); OR 1.39). RNA interference revealed that a MECOM knockdown suppresses osteoclastogenesis.
conclusionsOur findings provide new insights into the genetic architecture underlying OF in East Asians.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.