ArticleJournal of biochemical and molecular toxicology2013
Pesticides, microglial NOX2, and Parkinson's disease.
Article in Journal of biochemical and molecular toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Microglia Drive Pockets of Neuroinflammation in Middle Age.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Lanthanum Impairs Learning and Memory by Activating Microglia in the Hippocampus of Mice.Biological trace element research · 2022Article
- A Common Feature of Pesticides: Oxidative Stress-The Role of Oxidative Stress in Pesticide-Induced Toxicity.Oxidative medicine and cellular longevity · 2022Review
- Factors Influencing Practice of Pesticide Use and Acute Health Symptoms among Farmers in Nakhon Sawan, Thailand.International journal of environmental research and public health · 2021Article
- Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson's Disease Mouse Model.Journal of inflammation research · 2021Article
- Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms.Pharmacology & therapeutics · 2019Review
- Pesticides as the drivers of neuropsychotic diseases, cancers, and teratogenicity among agro-workers as well as general public.Environmental science and pollution research international · 2019Review
- Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures.Journal of neuroinflammation · 2018Article
- Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism.Brain research bulletin · 2017Review
- Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain.Physiological reports · 2017Article
- Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson's disease.Protoplasma · 2017Review
- Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review).Molecular medicine reports · 2016Review
- Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review).International journal of molecular medicine · 2016Review
- Monte Carlo cross-validation analysis screens pathway cross-talk associated with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Multifactorial theory applied to the neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease.Laboratory investigation; a journal of technical methods and pathology · 2016Review
- Crosstalk between Ca2+ signaling and mitochondrial H2O2 is required for rotenone inhibition of mTOR signaling pathway leading to neuronal apoptosis.Oncotarget · 2016Article
- Lipoic acid protects dopaminergic neurons in LPS-induced Parkinson's disease model.Metabolic brain disease · 2015Article
- Organochlorine insecticides induce NADPH oxidase-dependent reactive oxygen species in human monocytic cells via phospholipase A2/arachidonic acid.Chemical research in toxicology · 2015Article
- Excessive levels of nitric oxide in rat model of Parkinson's disease induced by rotenone.Experimental and therapeutic medicine · 2015Article
- Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Accumulating evidence indicates that pesticide exposure is associated with an increased risk for developing Parkinson's disease (PD). Several pesticides known to damage dopaminergic (DA) neurons, such as paraquat, rotenone, lindane, and dieldrin also demonstrate the ability to activate microglia, the resident innate immune cell in the brain. While each of these environmental toxicants may impact microglia through unique mechanisms, they all appear to converge on a common final pathway of microglial activation: NADPH oxidase 2 (NOX2) activation. This review will detail the role of microglia in selective DA neurotoxicity, highlight what is currently known about the mechanism of microglial NOX2 activation in these key pesticides, and describe the importance for DA neuron survival and PD etiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.