ArticleDepression and anxiety2013
Youth genetic vulnerability to maternal depressive symptoms: 5-HTTLPR as moderator of intergenerational transmission effects in a multiwave prospective study.
Article in Depression and anxiety, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Longitudinal Coupling of Depression in Parent-Adolescent Dyads: Within- and Between-Dyad Effects Over Time.Clinical psychological science : a journal of the Association for Psychological Science · 2021Article
- Depression from childhood into late adolescence: Influence of gender, development, genetic susceptibility, and peer stress.Journal of abnormal psychology · 2015Article
- 5-HTTLPR × interpersonal stress interaction and nonsuicidal self-injury in general community sample of youth.Psychiatry research · 2015Article
- Cortisol reactivity to stress among youth: stability over time and genetic variants for stress sensitivity.Journal of abnormal psychology · 2015Article
- The Involvement of Genes in Adolescent Depression: A Systematic Review.Frontiers in behavioral neuroscience · 2015Review
- Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression.Psychoneuroendocrinology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMaternal depressive symptoms are a strong predictor of increases in depressive symptoms in offspring, yet knowledge of individual differences that may moderate the association between youth and maternal symptoms is still relatively scant. Youth genetic susceptibility to maternal depressive symptoms in particular is a nearly unexplored area of research.
methodsThis study used a multiwave prospective design and lagged hierarchical linear modeling analyses to examine whether youth 5-HTTLPR genotype moderated the longitudinal association between mother and youth depressive symptoms in a community sample (N = 241 youth). Maternal and youth symptoms were assessed every 3 months over 1 year (five waves of data).
resultsYouth 5-HTTLPR interacted with idiographic elevations in maternal depressive symptoms (elevations relative to mothers' average level of symptoms) to predict prospective increases in youth symptoms 3 months later. Youth with the SS genotype experienced greatest increases in depressive symptoms when exposed to elevations in maternal symptoms. Youth 5-HTTLPR did not interact with maternal nomothetic elevations in depressive symptoms (severity of symptoms compared to the sample as a whole).
conclusionThese findings advance knowledge on genetic susceptibility for intergenerational transmission of depression between mothers and their children.
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