ArticleThe Pediatric infectious disease journal2013
Polymicrobial acute respiratory infections in a hospital-based pediatric population.
Article in The Pediatric infectious disease journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Transcriptome assists prognosis of disease severity in respiratory syncytial virus infected infants.Scientific reports · 2016Trial
- Prevalence, characteristics and outcomes of respiratory viral co-infection among hospitalized children.European journal of pediatrics · 2026Article
- [Epidemiology, Mechanisms, and Clinical Challenges of Respiratory Syncytial Virus Co-infections in Children].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Clinico-virological Profile, Intensive Care Needs, and Outcome of Infants with Acute Viral Bronchiolitis: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Respiratory Virus Co-infection in Acute Respiratory Infections in Children.Current infectious disease reports · 2020Review
- Viral Surveillance of Children with Acute Respiratory Infection in Two Main Hospitals in Northern Jordan, Irbid, during Winter of 2016.Journal of pediatric infectious diseases · 2020Article
- Article
- Role of viral and bacterial pathogens in causing pneumonia among Western Australian children: a case-control study protocol.BMJ open · 2018Article
- Quantitative detection of human Malawi polyomavirus in nasopharyngeal aspirates, sera, and feces in Beijing, China, using real-time TaqMan-based PCR.Virology journal · 2017Article
- Does Viral Co-Infection Influence the Severity of Acute Respiratory Infection in Children?PloS one · 2016Article
- Respiratory syncytial virus, adenoviruses, and mixed acute lower respiratory infections in children in a developing country.Journal of medical virology · 2015Article
- Detection of viral and bacterial pathogens in hospitalized children with acute respiratory illnesses, Chongqing, 2009-2013.Medicine · 2015Article
- Viral aetiology of acute respiratory infections among children and associated meteorological factors in southern China.BMC infectious diseases · 2015Article
- Blood MxA protein as a marker for respiratory virus infections in young children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015Article
- Viral Co-Infections in Pediatric Patients Hospitalized with Lower Tract Acute Respiratory Infections.PloS one · 2015Article
- Respiratory infections in Eñepa Amerindians are related to malnutrition and Streptococcus pneumoniae carriage.The Journal of infection · 2013Article
- Virome genomics: a tool for defining the human virome.Current opinion in microbiology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe clinical impact of polymicrobial respiratory infections remains uncertain. Previous reports are contradictory regarding an association with severe disease.
methodsThree hundred forty-six specimens from children with acute respiratory illness identified at the University of Iowa Hospitals and Clinics Clinical Microbiology Laboratory were evaluated by direct immunofluorescent assay and/or viral culture by Clinical Microbiology Laboratory and later by molecular study for the presence of influenza, parainfluenza, respiratory syncytial virus, adenovirus, human metapneumovirus, rhinovirus and human bocavirus. Demographic and clinical data were abstracted from medical records.
resultsMultiple viruses were detected in 46 (21.7%) of 212 virus-positive specimens with the most frequent virus-virus combinations being HRV-respiratory syncytial virus (n = 12), HRV-human bocavirus (n = 6) and HRV-parainfluenza virus 3 (n = 4). Risk factors for coinfection included male gender (OR [odds ratio]: 1.70, 95% confidence interval [CI]: 0.83-3.46), 6 months to 1 year age (OR: 2.15, 95% CI: 0.75-6.19) and history of immunosuppression (OR: 2.05, 95% CI: 0.99-4.23). Children with viral coinfections were less likely than children with single virus infections to be admitted to an intensive care unit (OR: 0.32, 95% CI: 0.08-1.27); however, this may be explained by undetected viral-bacterial coinfections.
conclusionsHRV, respiratory syncytial virus, human bocavirus, and polymicrobial infections were prevalent in this study. Although the cross-sectional design could not easily examine polymicrobial infection and disease severity, prospective, population-based research regarding the clinical impact of such infections is warranted.
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