Evidence map›Paper›PMID 23348416›Full record

ReviewNature reviews. Immunology2013

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes.

Andrea Cerutti, Montserrat Cols, Irene Puga

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 443 papers.

0numbers the graph read from it
0cells of the map it votes in
443citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

443 citing papers in PubMed.

  1. Trial
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  5. Review
  6. T Cell Thoughts.Immunological reviews · 2026
    Review
  7. Review
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  16. Review
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383 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrea CeruttiCatalan Institute for Research and Advanced Studies, Barcelona Biomedical Research Park, Barcelona, Spain. acerutti@imim.es
Montserrat Cols
Irene Puga

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
Role of Follicular T Helper Cells In Enhancing Humoral Immunity and ProtectionU19AI096187 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO · 2011 to 2015
$26.5M
Regulation of antibody production by innate signalsR01AI057653 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2005 to 2016
$4.3M
Regulation of antibody diversification and production in HIV-1 infectionR01AI074378 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2008 to 2012
$2.1M
Regulation and Function of Immunoglobulin D in Mucosal Immune DefenseU01AI095613 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA · 2011 to 2015
$2.1M
NIAID NIH HHS AI074378NIAID NIH HHS AI61093NIAID NIH HHS AI95613NIAID NIH HHS AI96187NIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI057653NIAID NIH HHS R01 AI074378NIAID NIH HHS U01 AI095613NIAID NIH HHS U19 AI096187
6 · The paper itself

Abstract

Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the circulation and lymphoid tissue, splenic marginal zone B cells rapidly respond to blood-borne antigens by adopting 'crossover' defensive strategies that blur the conventional boundaries of innate and adaptive immunity. This Review discusses how marginal zone B cells function as innate-like lymphocytes that mount rapid antibody responses to both T cell-dependent and T cell-independent antigens. These responses require the integration of activation signals from germline-encoded and somatically recombined receptors for microorganisms with helper signals from effector cells of the innate and adaptive immune systems.

Indexed as

Antibody FormationImmunity, InnateAnimalsAntigensB-LymphocytesHumansImmunoglobulin Class SwitchingLymphoid TissueMutationProtein BindingSignal TransductionAntigens

Identifiers

PMID23348416
PMCPMC3652659

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.