ArticleGenome biology and evolution2013
Contrasted evolution of the vomeronasal receptor repertoires in mammals and squamate reptiles.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Genomic structural variation rescues a classic biological invader from a population bottleneck.Science advances · 2026Article
- Arboreal Squirrels Have a Segregated Vomeronasal System With a Regressed Type 2 Receptor (V2R)-Domain.The Journal of comparative neurology · 2026Article
- The Role of Olfaction in Dogs: Evolution, Biology, and Human-Oriented Work.Animals : an open access journal from MDPI · 2026Review
- Unravelling the thread of Podarcis omics; insights into the genome and transcriptome of the Cretan wall lizard.Genes & genomics · 2026Article
- How Foraging Mode Sculpts Sensory Systems: Morphological Evidence From DiceCT and Histology in Sympatric Lizards.Ecology and evolution · 2025Article
- Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species.eLife · 2024Article
- Synchronized Expansion and Contraction of Olfactory, Vomeronasal, and Taste Receptor Gene Families in Hystricomorph Rodents.Molecular biology and evolution · 2024Article
- Dynamic evolutionary interplay between ontogenetic skull patterning and whole-head integration.Nature ecology & evolution · 2024Article
- Histological features and GαJournal of anatomy · 2023Article
- In situ hybridization analysis of olfactory receptor expression in the sea turtle olfactory organ.Cell and tissue research · 2023Article
- Vomeronasal Receptors Associated with Circulating Estrogen Processing Chemosensory Cues in Semi-Aquatic Mammals.International journal of molecular sciences · 2023Article
- Remarkable diversity of vomeronasal type 2 receptor (OlfC) genes of basal ray-finned fish and its evolutionary trajectory in jawed vertebrates.Scientific reports · 2022Article
- Inflammation interferes with chemoreception in pigs by altering the neuronal layout of the vomeronasal sensory epithelium.Frontiers in veterinary science · 2022Article
- Genome assembly of the numbat (GigaByte (Hong Kong, China) · 2022Article
- Evolutionary insights into umami, sweet, and bitter taste receptors in amphibians.Ecology and evolution · 2021Article
- Two Reference-Quality Sea Snake Genomes Reveal Their Divergent Evolution of Adaptive Traits and Venom Systems.Molecular biology and evolution · 2021Article
- The Chemosensory Repertoire of the Eastern Diamondback Rattlesnake (Crotalus adamanteus) Reveals Complementary Genetics of Olfactory and Vomeronasal-Type Receptors.Journal of molecular evolution · 2021Article
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Genome mapping of aProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Olfactory receptor gene evolution is unusually rapid across Tetrapoda and outpaces chemosensory phenotypic change.Current zoology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vomeronasal organ (VNO) is an olfactory structure that detects pheromones and environmental cues. It consists of sensory neurons that express evolutionary unrelated groups of transmembrane chemoreceptors. The predominant V1R and V2R receptor repertoires are believed to detect airborne and water-soluble molecules, respectively. It has been suggested that the shift in habitat of early tetrapods from water to land is reflected by an increase in the ratio of V1R/V2R genes. Snakes, which have a very large VNO associated with a sophisticated tongue delivery system, are missing from this analysis. Here, we use RNA-seq and RNA in situ hybridization to study the diversity, evolution, and expression pattern of the corn snake vomeronasal receptor repertoires. Our analyses indicate that snakes and lizards retain an extremely limited number of V1R genes but exhibit a large number of V2R genes, including multiple lineages of reptile-specific and snake-specific expansions. We finally show that the peculiar bigenic pattern of V2R vomeronasal receptor gene transcription observed in mammals is conserved in squamate reptiles, hinting at an important but unknown functional role played by this expression strategy. Our results do not support the hypothesis that the shift to a vomeronasal receptor repertoire dominated by V1Rs in mammals reflects the evolutionary transition of early tetrapods from water to land. This study sheds light on the evolutionary dynamics of the vomeronasal receptor families in vertebrates and reveals how mammals and squamates differentially adapted the same ancestral vomeronasal repertoire to succeed in a terrestrial environment.
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