ArticleNeuropharmacology2013
Cocaine facilitates glutamatergic transmission and activates lateral habenular neurons.
Article in Neuropharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- The Habenula's role in major depressive disorder: recent insights from preclinical and human studies.Translational psychiatry · 2026Review
- A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine.Science advances · 2025Article
- Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats.Acta pharmacologica Sinica · 2024Article
- Compulsive drug-taking is associated with habenula-frontal cortex connectivity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The circadian clock in the mouse habenula is set by catecholamines.Cell and tissue research · 2022Article
- Potentiation of glutamatergic synaptic transmission onto lateral habenula neurons following early life stress and intravenous morphine self-administration in rats.Addiction biology · 2022Article
- Acetaldehyde Excitation of Lateral Habenular Neurons via Multiple Cellular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula.Neurobiology of stress · 2020Article
- Activation of glycine receptors in the lateral habenula rescues anxiety- and depression-like behaviors associated with alcohol withdrawal and reduces alcohol intake in rats.Neuropharmacology · 2019Article
- Elevation of Transient Receptor Potential Vanilloid 1 Function in the Lateral Habenula Mediates Aversive Behaviors in Alcohol-withdrawn Rats.Anesthesiology · 2019Article
- A Focus on Reward Prediction and the Lateral Habenula: Functional Alterations and the Behavioral Outcomes Induced by Drugs of Abuse.Frontiers in synaptic neuroscience · 2018Review
- Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats.Neuropharmacology · 2017Article
- Lateral Habenula Involvement in Impulsive Cocaine Seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons.Addiction biology · 2017Article
- Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms.Scientific reports · 2016Article
- Pharmacological modulation of lateral habenular dopamine D2 receptors alters the anxiogenic response to cocaine in a runway model of drug self-administration.Behavioural brain research · 2016Article
- High Frequency Electrical Stimulation of Lateral Habenula Reduces Voluntary Ethanol Consumption in Rats.The international journal of neuropsychopharmacology · 2016Article
- Serotonin modulates glutamatergic transmission to neurons in the lateral habenula.Scientific reports · 2016Article
- Serotonin stimulates lateral habenula via activation of the post-synaptic serotonin 2/3 receptors and transient receptor potential channels.Neuropharmacology · 2016Article
- Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.Nature neuroscience · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Cocaine administration can be both rewarding and aversive. While much effort has gone to investigating the rewarding effect, the mechanisms underlying cocaine-induced aversion remain murky. There is increasing evidence that the lateral habenula (LHb), a small epithalamic structure, plays a critical role in the aversive responses of many addictive drugs including cocaine. However, the effects of cocaine on LHb neurons are not well explored. Here we show that, in acute brain slices from rats, cocaine depolarized LHb neurons and accelerated their spontaneous firing. The AMPA and NMDA glutamate receptor antagonists, 6, 7-dinitroquinoxaline-2, 3-dione, DL-2-amino-5-phosphono-valeric acid, attenuated cocaine-induced acceleration. In addition, cocaine concentration-dependently enhanced glutamatergic excitation: enhanced the amplitude but reduced the paired pulse ratio of EPSCs elicited by electrical stimulations, and increased the frequency of spontaneous EPSCs in the absence and presence of tetrodotoxin. Dopamine and the agonists of dopamine D1 (SKF 38393) and D2 (quinpirole) receptors, as well as the dopamine transporter blocker (GBR12935), mimicked the effects of cocaine. Conversely, both D1 (SKF83566) and D2 (raclopride) antagonists substantially attenuated cocaine's effects on EPSCs and firing. Together, our results provide evidence that cocaine may act primarily via an increase in dopamine levels in the LHb that activates both D1 and D2 receptors. This leads to an increase in presynaptic glutamate release probability and LHb neuron activity. This may contribute to the aversive effect of cocaine observed in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.