ReviewPaediatric respiratory reviews2013
New molecular virus detection methods and their clinical value in lower respiratory tract infections in children.
Review in Paediatric respiratory reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03233516 (Trial of Respiratory Infections in Children for Enhanced Diagnostics), which is not on this map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of Respiratory Infections in Children for Enhanced Diagnostics
Who cites it
49 citing papers in PubMed, 103 citations in OpenAlex.
- Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode.The Journal of allergy and clinical immunology · 2015Trial
- Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2013Trial
- Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries.Health science reports · 2026Article
- Article
- Epidemiological Characteristics of Upper Respiratory Tract Pathogens in Children in Guangdong, China.The clinical respiratory journal · 2024Article
- Impact of Respiratory Viruses and SARS-CoV-2 on Febrile Seizures in Saudi Children: Insights into Etiologies, Gender, and Familial Associations.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Viruses associated with acute respiratory infection in a community-based cohort of healthy New Zealand children.Journal of medical virology · 2022Article
- Article
- An IoT Framework for Screening of COVID-19 Using Real-Time Data from Wearable Sensors.International journal of environmental research and public health · 2021Article
- Article
- Viral etiologies of acute respiratory tract infections among hospitalized children - A comparison between single and multiple viral infections.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2019Article
- Introducing a New Algorithm for Classification of Etiology in Studies on Pediatric Pneumonia: Protocol for the Trial of Respiratory Infections in Children for Enhanced Diagnostics Study.JMIR research protocols · 2019Article
- Effect of stochasticity on coinfection dynamics of respiratory viruses.BMC bioinformatics · 2019Article
- Detection of six common human paramyxoviruses in patients with acute febrile respiratory symptoms using a novel multiplex real-time RT-PCR assay.Journal of medical virology · 2019Article
- Respiratory Testing and Hospital Outcomes in Asymptomatic Infants Undergoing Heart Surgery.Pediatric cardiology · 2019Observational
- Respiratory virus detection and co-infection in children and adults in a large Australian hospital in 2009-2015.Journal of paediatrics and child health · 2018Observational
- Viruses causing lower respiratory symptoms in young children: findings from the ORChID birth cohort.Thorax · 2018Observational
- [Short-term relevance of lower respiratory viral coinfection in inpatients under 2 years of age].Anales de pediatria · 2018Observational
- Short-term relevance of lower respiratory viral coinfection in inpatients under 2 years of age.Anales de pediatria · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the past decade, several new respiratory viruses and their subgroups have been discovered. All these new viruses, as well as previously known respiratory viruses, can be detected by sensitive PCR methods, which have become popular in the diagnostic workup of respiratory viral infections. Currently, respiratory viruses can be detected in up to 95% of children with lower respiratory tract illness. On the other hand, virus detection rates in asymptomatic children are also high (up to 68%), as are coinfection rates in symptomatic children (up to 43%) and justified concerns of causality have been raised. Imposing progress has been made in developing multiplex quantitative PCR assays; here, several primer sets are run within a single PCR mixture. These PCR assays give a better understanding of the dominant viral infection, of viral infections that may be incipient and of any waning infections than does a single-target PCR. Multiplex PCR assays are also gaining popularity due to their cost-effectiveness and short throughput time compared to multiple single-target PCRs. Our understanding of the indications of virus PCRs and our ability to interpret the results from a clinical point of view have improved. This paper reviews the progress in PCR assays and discusses their role in the diagnosis of lower respiratory tract infections in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.