Evidence map›Paper›PMID 23347657›Full record

ReviewPaediatric respiratory reviews2013

Perinatal exposure to alcohol: implications for lung development and disease.

Danielle Giliberti, Sowmya S Mohan, Lou Ann S Brown, Theresa W Gauthier

Abstract readReview
In one paragraph

Review in Paediatric respiratory reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2018
    Review
  2. Article
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Danielle GilibertiDepartment of Paediatrics, Division of Neonatal-Perinatal Medicine, Emory University, Emory Children's Centre for Developmental Lung Biology, 2015 Uppergate Dr. NE, Atlanta, GA 30322, USA. danielle.giliberti@emory.edu
Sowmya S Mohan
Lou Ann S Brown
Theresa W Gauthier
Emory University · US

Funding

THE ROLE OF TGFB IN ETHANOL MEDIATED LUNG INJURYP50AA013757 · NIAAA · EMORY UNIVERSITY · PI GUIDOT, DAVID MARSHALL · 2003 to 2013
$15.7M
Institutional Training Grant in Alcohol ResearchT32AA013528 · NIAAA · EMORY UNIVERSITY · PI GUIDOT, DAVID MARSHALL · 2002 to 2011
$3.2M
In Utero Alcohol and Alveolar Macrophage Maturation-A Risk For The NewbornR01AA016348 · NIAAA · EMORY UNIVERSITY · PI GAUTHIER, THERESA WANZOR · 2008 to 2012
$1.7M
The Effects of Fatty Acid Ethyl Esters on the Developing LungF32AA019880 · NIAAA · EMORY UNIVERSITY · PI MOHAN, SOWMYA S · 2010 to 2010
$50k
NIAAA NIH HHS 1 F32AA019880-01NIAAA NIH HHS 1P50 AA013757NIAAA NIH HHS 1R01AA016348NIAAA NIH HHS 5T32AA013528-10NIAAA NIH HHS F32 AA019880NIAAA NIH HHS P50 AA013757NIAAA NIH HHS R01 AA016348NIAAA NIH HHS T32 AA013528
6 · The paper itself

Abstract

In utero alcohol exposure dramatically increases the risk of premature delivery. However, the majority of premature and term newborns exposed to alcohol remain undetected by medical caregivers. There is a desperate need for reliable and accurate biomarkers of alcohol exposure for the term and premature newborn population. The inability to identify the exposed newborn severely limits our understanding of alcohol's pathophysiological effects on developing organs such as the lung. This chapter will review potential advancements in future biomarkers of alcohol exposure for the newborn population. We will discuss alcohol's effects on redox homeostasis and cellular development of the neonatal lung. Finally, we will present the evidence describing in utero alcohol's derangement of innate and adaptive immunity and risk for infectious complications in the lung. Continued investigations into the identification and understanding of the mechanisms of alcohol-induced alterations in the premature lung will advance the care of this vulnerable patient population.

Indexed as

Lung DiseasesAlcohol DrinkingEthanolFemaleGlobal HealthHumansIncidenceInfant, NewbornLungPregnancyPrenatal Exposure Delayed EffectsEthanol

Identifiers

PMID23347657
PMCPMC3556383
OpenAlexW2034076029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.