ArticleBMC microbiology2013
Antimicrobial activity, antibiotic susceptibility and virulence factors of Lactic Acid Bacteria of aquatic origin intended for use as probiotics in aquaculture.
Article in BMC microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 233 citations in OpenAlex.
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- Genomic and functional characterization of Bacillus siamensis AFSC23 isolated from the gut of European conger (Conger conger) as a probiotic candidate for aquaculture.BMC microbiology · 2026Article
- A Novel Lactococcus Lactis LZK-02 Strain Antagonistic to Staphylococcus Aureus: In Vitro Probiotic Profiling and in Vivo Benefits as Feed Additive in Micropterus Salmoides.Probiotics and antimicrobial proteins · 2026Article
- Extraction, Purification, and Characterization of a Bacteriocin from MarineMicroorganisms · 2026Article
- Genetically Modified Microorganisms: Risks and Regulatory Considerations for Human and Environmental Health.Microorganisms · 2026Review
- Potential Lactic Acid Bacteria Characterized From the Gastrointestinal Tract of Butter Catfish,International journal of microbiology · 2026Article
- Genomic and phenotypic analysis ofFrontiers in microbiology · 2026Article
- Multi-strain Native Probiotics from the Asian Stinging Catfish (Heteropneustes fossilis) Enhance Growth, Blood Health, and Organ Morphology in the Host.Probiotics and antimicrobial proteins · 2025Article
- Antimicrobial Activity, Genetic Diversity and Safety Assessment of Lactic Acid Bacteria Isolated from European Hakes (Antibiotics (Basel, Switzerland) · 2025Article
- In vitro characterization of lactic acid bacteria and bifidobacteria from wild and domestic pigs: probiotic potential for post-weaning piglets.BMC microbiology · 2025Article
- Article
- Isolation, Genomics-Based and Biochemical Characterization of Bacteriocinogenic Bacteria and Their Bacteriocins, Sourced from the Gastrointestinal Tract of Meat-Producing Pigs.International journal of molecular sciences · 2024Article
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- Probiotic Strain Limosilactobacillus reuteri 29B is Proven Safe and Exhibits Potential Probiotic Traits in a Murine Vaginal Model.Probiotics and antimicrobial proteins · 2024Article
- Antimicrobial Activity, Genetic Relatedness, and Safety Assessment of Potential Probiotic Lactic Acid Bacteria Isolated from a Rearing Tank of Rotifers (Animals : an open access journal from MDPI · 2024Article
- Lactic Acid Bacteria of Marine Origin as a Tool for Successful Shellfish Farming and Adaptation to Climate Change Conditions.Foods (Basel, Switzerland) · 2024Review
- Assessment of safety and in situ antibacterial activity of Weissella cibaria strains isolated from dairy farms in Minas Gerais State, Brazil, for their food application.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Novel Wild-TypeMicroorganisms · 2024Article
- Emerging antibiotic resistance inSustainable microbiology · 2024Article
- Genomic and Functional Evaluation of TwoGenes · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe microorganisms intended for use as probiotics in aquaculture should exert antimicrobial activity and be regarded as safe not only for the aquatic hosts but also for their surrounding environments and humans. The objective of this work was to investigate the antimicrobial/bacteriocin activity against fish pathogens, the antibiotic susceptibility, and the prevalence of virulence factors and detrimental enzymatic activities in 99 Lactic Acid Bacteria (LAB) (59 enterococci and 40 non-enterococci) isolated from aquatic animals regarded as human food.
resultsThese LAB displayed a broad antimicrobial/bacteriocin activity against the main Gram-positive and Gram-negative fish pathogens. However, particular safety concerns based on antibiotic resistance and virulence factors were identified in the genus Enterococcus (86%) (Enterococcus faecalis, 100%; E. faecium, 79%). Antibiotic resistance was also found in the genera Weissella (60%), Pediococcus (44%), Lactobacillus (33%), but not in leuconostocs and lactococci. Antibiotic resistance genes were found in 7.5% of the non-enterococci, including the genera Pediococcus (12.5%) and Weissella (6.7%). One strain of both Pediococcus pentosaceus and Weissella cibaria carried the erythromycin resistance gene mef(A/E), and another two P. pentosaceus strains harboured lnu(A) conferring resistance to lincosamides. Gelatinase activity was found in E. faecalis and E. faecium (71 and 11%, respectively), while a low number of E. faecalis (5%) and none E. faecium exerted hemolytic activity. None enterococci and non-enterococci showed bile deconjugation and mucin degradation abilities, or other detrimental enzymatic activities.
conclusionsTo our knowledge, this is the first description of mef(A/E) in the genera Pediococcus and Weissella, and lnu(A) in the genus Pediococcus. The in vitro subtractive screening presented in this work constitutes a valuable strategy for the large-scale preliminary selection of putatively safe LAB intended for use as probiotics in aquaculture.
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