ReviewMagnetic resonance imaging2013
Visualizing iron in multiple sclerosis.
Review in Magnetic resonance imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Ferroptosis in microglial activation: a systematic review and multidata comparison.Brain communications · 2026Review
- Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases.Biological trace element research · 2024Review
- Iron metabolism disorder and multiple sclerosis: a comprehensive analysis.Frontiers in immunology · 2024Article
- Iron Heterogeneity in Early Active Multiple Sclerosis Lesions.Annals of neurology · 2021Article
- Iron Rims in Patients With Multiple Sclerosis as Neurodegenerative Marker? A 7-Tesla Magnetic Resonance Study.Frontiers in neurology · 2021Article
- Metal Imbalance in Neurodegenerative Diseases with a Specific Concern to the Brain of Multiple Sclerosis Patients.International journal of molecular sciences · 2020Review
- Volumetric imaging of myelin in vivo using 3D inversion recovery-prepared ultrashort echo time cones magnetic resonance imaging.NMR in biomedicine · 2020Article
- Can T2 blackout effect be a marker of iron accumulation in brains of multiple sclerosis patients?The British journal of radiology · 2020Article
- Imaging biomarkers in neurodegeneration: current and future practices.Alzheimer's research & therapy · 2020Review
- Assessment of mesoscopic properties of deep gray matter iron through a model-based simultaneous analysis of magnetic susceptibility and RNeuroImage · 2019Article
- Untangling the R2* contrast in multiple sclerosis: A combined MRI-histology study at 7.0 Tesla.PloS one · 2018Article
- Significance andFrontiers in immunology · 2018Review
- Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions.Acta neuropathologica · 2017Article
- Inversion recovery ultrashort echo time magnetic resonance imaging: A method for simultaneous direct detection of myelin and high signal demonstration of iron deposition in the brain - A feasibility study.Magnetic resonance imaging · 2017Article
- Magnetic Susceptibility from Quantitative Susceptibility Mapping Can Differentiate New Enhancing from Nonenhancing Multiple Sclerosis Lesions without Gadolinium Injection.AJNR. American journal of neuroradiology · 2016Article
- Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM).Journal of magnetic resonance imaging : JMRI · 2016Article
- Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping.International journal of molecular sciences · 2016Review
- Ultra-High-Field MRI Visualization of Cortical Multiple Sclerosis Lesions with T2 and T2*: A Postmortem MRI and Histopathology Study.AJNR. American journal of neuroradiology · 2015Article
- Multiple sclerosis lesion geometry in quantitative susceptibility mapping (QSM) and phase imaging.Journal of magnetic resonance imaging : JMRI · 2015Article
- Lateral ventricular cerebrospinal fluid diffusivity as a potential neuroimaging marker of brain temperature in multiple sclerosis: a hypothesis and implications.Magnetic resonance imaging · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Magnetic resonance imaging (MRI) protocols that are designed to be sensitive to iron typically take advantage of (1) iron effects on the relaxation of water protons and/or (2) iron-induced local magnetic field susceptibility changes. Increasing evidence sustains the notion that imaging iron in brain of patients with multiple sclerosis (MS) may add some specificity toward the identification of the disease pathology. The present review summarizes currently reported in vivo and post mortem MRI evidence of (1) iron detection in white matter and gray matter of MS brains, (2) pathological and physiological correlates of iron as disclosed by imaging and (3) relations between iron accumulation and disease progression as measured by clinical metrics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.