Evidence map›Paper›PMID 23347596›Full record

ReviewCurrent opinion in genetics & development2013

Chromatin dynamics at the replication fork: there's more to life than histones.

Iestyn Whitehouse, Duncan J Smith

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Iestyn WhitehouseMolecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. whitehoi@mskcc.org
Duncan J Smith

Funding

Okazaki Fragment Synthesis and Chromatin AssemblyR01GM102253 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI WHITEHOUSE, IESTYN · 2012 to 2020
$3.8M
Howard Hughes Medical Institute DRG-#2046-10NIGMS NIH HHS R01 GM102253
6 · The paper itself

Abstract

Before each division, eukaryotic cells face the daunting task of completely and accurately replicating a heterogeneous, chromatinized genome and repackaging both resulting daughters. Because replication requires strand separation, interactions between the DNA and its many associated proteins--including histones--must be transiently broken to allow the passage of the replication fork. Here, we will discuss the disruption and re-establishment of chromatin structure during replication, and the consequences of these processes for epigenetic inheritance.

Indexed as

Epigenesis, GeneticAnimalsChromatinChromosomal Proteins, Non-HistoneDNA-Binding ProteinsDNA ReplicationDrosophila melanogasterEuchromatinHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesNucleosomesTranscription FactorsChromatinChromosomal Proteins, Non-HistoneDNA-Binding ProteinsEuchromatinHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesNucleosomesTranscription Factors

Identifiers

PMID23347596
PMCPMC3657310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.