ReviewCritical reviews in toxicology2013
The use of biomonitoring data in exposure and human health risk assessment: benzene case study.
Review in Critical reviews in toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 158 citations in OpenAlex.
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- BTEX chrono-metabolism and leukemogenic effects of night shift work in workers of gasoline stations: the EXPOSOWORK prospective panel study in Bulgaria.Journal of the National Cancer Center · 2025Article
- Internal Exposure to BTEX in Tropical Children: Does Exposure Speed Up Pubertal Development?Antioxidants (Basel, Switzerland) · 2025Article
- Evaluation of synergistic factors on BTEX urinary biomarkers in motorcycle riders exposed to heavy traffic in a megacity.Scientific reports · 2025Article
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- Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM).Environment international · 2025Article
- Saliva as a non-invasive matrix for assessing xenobiotic metabolites and metabolomes: implications for maternal health and preeclampsia.International journal of oral science · 2025Article
- Exposures from Oil and Gas Development and Childhood Leukemia Risk in Colorado: A Population-Based Case-Control Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Mediating effect of oxidative stress on blood pressure elevation in workers exposed to low concentrations of benzene, toluene, and xylene (BTX).Scientific reports · 2024Article
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Evidence for reproductive health effects following exposure to hydraulic fracturing chemical mixtures.Reproduction (Cambridge, England) · 2024Review
- Occupational exposures and cancer risk in commercial laundry and dry cleaning industries: a scoping review.BMC public health · 2023Article
- Smoke exposure associated with higher urinary benzene biomarker muconic acid (MUCA) in Golestan Cohort Study participants.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2023Article
- Review
- Influence of Environmental Exposure to Steel Waste on Endocrine Dysregulation andInternational journal of environmental research and public health · 2023Article
- Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas.Toxics · 2022Review
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- Handheld Device for Selective Benzene Sensing over Toluene and Xylene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Research development and trends of benzene-induced leukemia from 1990 to 2019-A bibliometric analysis.Environmental science and pollution research international · 2022Review
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abstract A framework of "Common Criteria" (i.e. a series of questions) has been developed to inform the use and evaluation of biomonitoring data in the context of human exposure and risk assessment. The data-rich chemical benzene was selected for use in a case study to assess whether refinement of the Common Criteria framework was necessary, and to gain additional perspective on approaches for integrating biomonitoring data into a risk-based context. The available data for benzene satisfied most of the Common Criteria and allowed for a risk-based evaluation of the benzene biomonitoring data. In general, biomarker (blood benzene, urinary benzene and urinary S-phenylmercapturic acid) central tendency (i.e. mean, median and geometric mean) concentrations for non-smokers are at or below the predicted blood or urine concentrations that would correspond to exposure at the US Environmental Protection Agency reference concentration (30 µg/m(3)), but greater than blood or urine concentrations relating to the air concentration at the 1 × 10(-5) excess cancer risk (2.9 µg/m(3)). Smokers clearly have higher levels of benzene exposure, and biomarker levels of benzene for non-smokers are generally consistent with ambient air monitoring results. While some biomarkers of benzene are specific indicators of exposure, the interpretation of benzene biomonitoring levels in a health-risk context are complicated by issues associated with short half-lives and gaps in knowledge regarding the relationship between the biomarkers and subsequent toxic effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.