ArticleInnovations in clinical neuroscience2012
Deep brain stimulation: a novel strategy for treating Alzheimer's disease.
Article in Innovations in clinical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Effect of Age on Clinical Trial Outcome in Participants with Probable Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Trial
- Memory Prosthesis: Is It Time for a Deep Neuromimetic Computing Approach?Frontiers in neuroscience · 2019Article
- Status of Noninvasive Brain Stimulation in the Therapy of Alzheimer's Disease.Chinese medical journal · 2018Article
- Informant questionnaire on cognitive decline in the elderly (IQCODE) for assessing the severity of dementia in patients with Alzheimer's disease.BMC geriatrics · 2018Article
- Opening the debate on deep brain stimulation for Alzheimer disease - a critical evaluation of rationale, shortcomings, and ethical justification.BMC medical ethics · 2018Article
- Assessment of potential targets for deep brain stimulation in patients with Alzheimer's disease.Journal of clinical medicine research · 2015Review
- Longitudinal predictors of self-rated health and mortality in older adults.Preventing chronic disease · 2014Article
- Alzheimer's disease: The role for neurosurgery.Surgical neurology international · 2014Article
- Alzheimer's disease and the fornix.Frontiers in aging neuroscience · 2014Review
- Deep brain stimulation as a tool for improving cognitive functioning in Alzheimer's dementia: a systematic review.Frontiers in psychiatry · 2013Review
- Clinical implications of the new diagnostic guidelines for dementia.Innovations in clinical neuroscience · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Recent studies have identified an association between memory deficits and defects of the integrated neuronal cortical areas known collectively as the default mode network. It is conceivable that the amyloid deposition or other molecular abnormalities seen in patients with Alzheimer's disease may interfere with this network and disrupt neuronal circuits beyond the localized brain areas. Therefore, Alzheimer's disease may be both a degenerative disease and a broader system-level disorder affecting integrated neuronal pathways involved in memory. In this paper, we describe the rationale and provide some evidence to support the study of deep brain stimulation of the hippocampal fornix as a novel treatment to improve neuronal circuitry within these integrated networks and thereby sustain memory function in early Alzheimer's disease.
Identifiers
23346514PMC3552463What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.