ArticleJournal of the Korean Society of Coloproctology2012
Expression of placenta growth factor in colorectal carcinomas.
Article in Journal of the Korean Society of Coloproctology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Synchronous vascular endothelial growth factor protein profiles in both tissue and serum identify metastasis and poor survival in colorectal cancer.Scientific reports · 2019Trial
- Role of VEGFs/VEGFR-1 Signaling and its Inhibition in Modulating Tumor Invasion: Experimental Evidence in Different Metastatic Cancer Models.International journal of molecular sciences · 2020Review
- Using serum placenta growth factor could improve the sensitivity of colorectal cancer screening in fecal occult blood negative population: A multicenter with independent cohort validation study.Cancer medicine · 2019Article
- "Vessels in the Storm": Searching for Prognostic and Predictive Angiogenic Factors in Colorectal Cancer.International journal of molecular sciences · 2018Review
- Hypoxia activates placental growth factor expression in lymphatic endothelial cells.Oncotarget · 2017Article
- The significance of markers in the diagnosis of endometrial cancer.Przeglad menopauzalny = Menopause review · 2016Review
- Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.The Lancet. Oncology · 2015Article
- Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis.BMC cancer · 2015Article
- Prognostic significance of placenta growth factor expression in patients with multiple cancers: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Molecular profiling in the treatment of colorectal cancer: focus on regorafenib.OncoTargets and therapy · 2015Review
- Epigenetic control of hypoxia inducible factor-1α-dependent expression of placental growth factor in hypoxic conditions.Epigenetics · 2014Article
- Ziv-aflibercept in metastatic colorectal cancer.Biologics : targets & therapy · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePlacenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family. PlGF is implicated in several pathologic processes, including the growth and spread of cancer and tumor angiogenesis. The aim of this study was to evaluate the expression and the clinical implications of PlGF in colorectal cancer.
methodsIn order to ascertain the clinical significance of PlGF expression in colorectal cancer, the researcher analyzed the expression pattern of PlGF by using an immunohistochemical method and attempted to establish if a relationship existed between PlGF expression and microvessel density (MVD), and subsequently between PlGF expression and the predicted prognosis. A total of 83 patients with colorectal cancer were included for immunohistochemical staining. Clinicopathological characteristics were defined according to the tumor-node-metastasis (TNM) criteria of the Union for International Cancer Control. Clinicopathologic factors, such as age, sex, histological types of tumors, tumor cell grade, TNM stage, lymphovascular invasion, and lymph-node metastasis, were reviewed.
resultsIn this study, the PlGF protein expression level was significantly correlated with MVD, patient survival, and clinicopathological factors such as lymph-node metastasis, TNM staging, lymphatic invasion and vascular invasion.
conclusionPlGF may be an important angiogenic factor in human colorectal cancer, and in this study, PlGF expression level was significantly correlated with positive lymph-node metastases, tumor stage, and patient survival. These findings suggest that PlGF expression correlates with disease progression and may be used as a prognostic marker for colorectal cancer.
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