ArticleInternational journal of breast cancer2012
A comparison of cholesterol uptake and storage in inflammatory and noninflammatory breast cancer cells.
Article in International journal of breast cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Cellular context and ligand class shape CXCR4-CCR5 heteromerization in live cells.Research square · 2026Article
- MCPB-21 targets glycogenin-2 to regulate fatty acid oxidation and promote ferroptosis of breast cancer.American journal of cancer research · 2026Article
- Cholesterol in colorectal cancer: an essential but tumorigenic precursor?Frontiers in oncology · 2023Review
- Assembly of Tetraspanin-enriched macrodomains contains membrane damage to facilitate repair.Nature cell biology · 2022Article
- In Vitro Investigations of miR-33a Expression in Estrogen Receptor-Targeting Therapies in Breast Cancer Cells.Cancers · 2021Article
- Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor.Pharmacological research · 2020Article
- Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains.Nature cell biology · 2019Article
- Metformin exhibited anticancer activity by lowering cellular cholesterol content in breast cancer cells.PloS one · 2019Article
- Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation.Scientific reports · 2017Article
- Impact of Statin Use on Outcomes in Triple Negative Breast Cancer.Journal of Cancer · 2017Article
- Is cholesterol a mediator of cold-induced cancer?Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- MiR-33a Decreases High-Density Lipoprotein-Induced Radiation Sensitivity in Breast Cancer.International journal of radiation oncology, biology, physics · 2016Article
- High-density and very-low-density lipoprotein have opposing roles in regulating tumor-initiating cells and sensitivity to radiation in inflammatory breast cancer.International journal of radiation oncology, biology, physics · 2015Article
- Targeting Intracellular Cholesterol is a Novel Therapeutic Strategy for Cancer Treatment.Journal of cancer science & therapy · 2014Article
- Simvastatin radiosensitizes differentiated and stem-like breast cancer cell lines and is associated with improved local control in inflammatory breast cancer patients treated with postmastectomy radiation.Stem cells translational medicine · 2014Article
- Cholesterol transport and regulation in the mammary gland.Journal of mammary gland biology and neoplasia · 2014Review
- Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression.BMC cancer · 2014Article
- Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although there are many subtypes of breast cancer, inflammatory breast cancer (IBC) is arguably the deadliest. Research over the past decade has demonstrated that IBC is a distinct entity from other forms of breast cancer. Important risk factors that have been associated with the development of aggressive breast cancers, such as IBC, include obesity and diet, which are evident in the United States, where the overconsumption of high-fat foods continues to contribute to obesity in the nation. Here we investigate differences in cholesterol uptake and storage between IBC, non-IBC, and mammary epithelial cell lines. Our results demonstrate that compared with human mammary epithelial cells (HMECs), both IBC and non-IBC cells have increased cholesterol content. IBC cells retain intracellular cholesterol esters, free cholesterol, and triglycerides in lipid-deficient environments. In contrast, we observe in cell-type-of-origin-matched non-IBC a significant decrease in lipid content under the same lipid-deficient conditions. These data suggest that cholesterol storage may be affected by the cholesterol content of the environment where the tumor cell was isolated. Here, we suggest that breast cancer cells may migrate when they are unable to obtain cholesterol from their extracellular environments.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.