ArticleScientific reports2013
Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Obesogenic Diets Composition Differentially Alters theNutrients · 2026Article
- Precision microbiome medicine and therapeutics: the enabling role of in vitro gut models.FEMS microbiology reviews · 2026Review
- Regulatory effect ofFrontiers in microbiology · 2024Review
- Gut Serpinome: Emerging Evidence in IBD.International journal of molecular sciences · 2021Review
- Lactobacillus rhamnosus GG modifies the metabolome of pathobionts in gnotobiotic mice.BMC microbiology · 2021Article
- Antibiotic administration exacerbates acute graft vs. host disease-induced bone marrow and spleen damage in lymphopenic mice.PloS one · 2021Article
- Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.Nature communications · 2019Article
- Current applications of fecal microbiota transplantation in intestinal disorders.The Kaohsiung journal of medical sciences · 2019Review
- Escherichia coli promotes DSS‑induced murine colitis recovery through activation of the TLR4/NF‑κB signaling pathway.Molecular medicine reports · 2019Article
- Patchouli Essential Oil and Its Derived Compounds Revealed Prebiotic-Like Effects in C57BL/6J Mice.Frontiers in pharmacology · 2019Article
- NADPH oxidases and ROS signaling in the gastrointestinal tract.Mucosal immunology · 2018Review
- Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota.Inflammatory bowel diseases · 2018Article
- Establishing a mucosal gut microbial community in vitro using an artificial simulator.PloS one · 2018Article
- Host-microbial Cross-talk in Inflammatory Bowel Disease.Immune network · 2017Review
- Oral exposure to environmental pollutant benzo[a]pyrene impacts the intestinal epithelium and induces gut microbial shifts in murine model.Scientific reports · 2016Article
- Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.Nuclear receptor research · 2016Article
- Roles and regulation of the mucus barrier in the gut.Tissue barriers · 2015Article
- Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease.World journal of gastroenterology · 2014Review
- Mucosal healing and deep remission: what does it mean?World journal of gastroenterology · 2013Review
- Discordance between changes in the gut microbiota and pathogenicity in a mouse model of spontaneous colitis.Gut microbesArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We compared fecal microbial communities derived either from Ulcerative Colitis (UC) patients in remission (n = 4) or in relapse (n = 4), or from healthy subjects (n = 4). These communities were used for inoculation of a dynamic in vitro gut model, which contained integrated mucin-covered microcosms. We found that the microbiota of the 'mucus' largely differed from that of the 'lumen'. This was partly due to decreased mucus-associated populations of lactic acid producing bacterial populations (LAB), as LAB originating from UC patients had a significantly decreased capacity to colonize the mucin-covered microcosms as compared to those originating from healthy subjects. We found significant differences between the metabolomes of UC patients in relapse and remission, respectively, while the metabolome of patients in remission resembled that of healthy subjects. These novel findings constitute an important contribution to the understanding of the complex etiology of UC.
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