ArticleScientific reports2013
Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 35 citations in OpenAlex.
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- Discovering the potential of S. clavuligerus for bioactive compound production: cross-talk between the chromosome and the pSCL4 megaplasmid.BMC genomics · 2017Article
- The MtrAB two-component system controls antibiotic production in Streptomyces coelicolor A3(2).Microbiology (Reading, England) · 2017Article
- MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis.Scientific reports · 2017Article
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- The Conserved Actinobacterial Two-Component System MtrAB Coordinates Chloramphenicol Production with Sporulation inFrontiers in microbiology · 2017Article
- An assemblage of Frankia Cluster II strains from California contains the canonical nod genes and also the sulfotransferase gene nodH.BMC genomics · 2016Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
Understanding the evolution of virulence is key to appreciating the role specific loci play in pathogenicity. Streptomyces species are generally non-pathogenic soil saprophytes, yet within their genome we can find homologues of virulence loci. One example of this is the mammalian cell entry (mce) locus, which has been characterised in Mycobacterium tuberculosis. To investigate the role in Streptomyces we deleted the mce locus and studied its impact on cell survival, morphology and interaction with other soil organisms. Disruption of the mce cluster resulted in virulence towards amoebae (Acanthamoeba polyphaga) and reduced colonization of plant (Arabidopsis) models, indicating these genes may play an important role in Streptomyces survival in the environment. Our data suggest that loss of mce in Streptomyces spp. may have profound effects on survival in a competitive soil environment, and provides insight in to the evolution and selection of these genes as virulence factors in related pathogenic organisms.
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