ArticleNutrition research and practice2012
Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male.
Article in Nutrition research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Efficacy and Safety of TESTOPEAKAmerican journal of men's healthTrial
- Evaluation and research progress on rodent models of late-onset hypogonadism: a comprehensive review.The Canadian journal of urology · 2025Review
- Improvement of Late-Onset Hypogonadism Symptoms of FermentedNutrients · 2024Article
- A Review on the Impact of Oxidative Stress and Medicinal Plants on Leydig Cells.Antioxidants (Basel, Switzerland) · 2023Review
- The Effect of a Combination ofNutrients · 2022Article
- Vegetables and Their Bioactive Compounds as Anti-Aging Drugs.Molecules (Basel, Switzerland) · 2022Review
- Studies on the physicochemical characteristics of the New Zealand deer's tail,Food science and biotechnology · 2019Article
- MR-10 Enhances Men's Health by Improving Endogenous Male Sex Hormone Generation.Journal of medicinal food · 2018Article
- Steroidogenic effects ofAnimal cells and systems · 2018Article
- Validity and reliability of male andropause symptoms self-assessment questionnaire among elderly males in Khuzestan province of Iran.Journal of mid-life health · 2013Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was measured based on typical physiological stress. After daily intake of CRS-10 for 4 weeks, the level of testosterone, physical activity and both the number and activity of sperm in older rats (18 weeks) were measured. Furthermore, thirty males were surveyed with AMS (Aging Males' Symptoms) questionnaire after intake of 400 mg of CRS-10. Overall, CRS-10 protected TM3 cells from serum restriction and oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in rats were significantly enhanced. In addition, physical locomotion was markedly improved. Daily intake of 400 mg of CRS-10 improved the quality of life among agingmale respondents, according to a clinical survey using the AMS. The results indicate the potential of CRS-10 as a safe and efficacious natural substance for reducing or alleviating andropause symptoms.
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Registered trials
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