ReviewExperimental diabetes research2012
Animal models of diabetes mellitus for islet transplantation.
Review in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
- The Japanese Macaque as a Diabetes Recipient Animal Model for Porcine Islet Xenotransplantation.MedComm · 2026Article
- Insulin Deficiency Exacerbates Muscle Atrophy and Osteopenia inInternational journal of molecular sciences · 2025Article
- The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation.Redox biology · 2022Article
- NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes.Cell death & disease · 2022Article
- Diabetic Retinopathy: From Animal Models to Cellular Signaling.International journal of molecular sciences · 2022Review
- Cathinone: An alkaloid ofSaudi journal of biological sciences · 2021Article
- Improvement of islet transplantation by the fusion of islet cells with functional blood vessels.EMBO molecular medicine · 2021Article
- Intestinal Microbiota Play an Important Role in the Treatment of Type I Diabetes in Mice With BefA Protein.Frontiers in cellular and infection microbiology · 2021Article
- Metformin and Probiotics in the Crosstalk between Colitis-Associated Colorectal Cancer and Diabetes in Mice.Cancers · 2020Article
- Induction of diabetes in cynomolgus monkey with one shot of analytical grade streptozotocin.Animal models and experimental medicine · 2020Article
- Article
- Protective effect of ganoderic acid against the streptozotocin induced diabetes, inflammation, hyperlipidemia and microbiota imbalance in diabetic rats.Saudi journal of biological sciences · 2019Article
- Caffeic Acid Modulates miR-636 Expression in Diabetic Nephropathy Rats.Indian journal of clinical biochemistry : IJCB · 2019Article
- Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes.Journal of cellular physiology · 2017Article
- Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice.Journal of visualized experiments : JoVE · 2017Article
- 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.Journal of the American Chemical Society · 2017Article
- Comparison of the response using ICR mice derived from three different sources to multiple low-dose streptozotocin-induced diabetes mellitus.Laboratory animal research · 2017Article
- Changes in the Diaphragm Lipid Content after Administration of Streptozotocin and High-Fat Diet Regime.Journal of diabetes research · 2017Article
- A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice.Nature communications · 2016Article
- WTC rat has unique characteristics such as resistant to streptozotocin.Biochemistry and biophysics reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to current improvements in techniques for islet isolation and transplantation and protocols for immunosuppressants, islet transplantation has become an effective treatment for severe diabetes patients. Many diabetic animal models have contributed to such improvements. In this paper, we focus on 3 types of models with different mechanisms for inducing diabetes mellitus (DM): models induced by drugs including streptozotocin (STZ), pancreatomized models, and spontaneous models due to autoimmunity. STZ-induced diabetes is one of the most commonly used experimental diabetic models and is employed using many specimens including rodents, pigs or monkeys. The management of STZ models is well established for islet studies. Pancreatomized models reveal different aspects compared to STZ-induced models in terms of loss of function in the increase and decrease of blood glucose and therefore are useful for evaluating the condition in total pancreatomized patients. Spontaneous models are useful for preclinical studies including the assessment of immunosuppressants because such models involve the same mechanisms as type 1 DM in the clinical setting. In conclusion, islet researchers should select suitable diabetic animal models according to the aim of the study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.