ArticleFrontiers in neuroscience2012
Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit.
Article in Frontiers in neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Dual Effects of ADHD Pharmacotherapy on Nutrition: A Scoping Review of Appetite, Eating Behavior, and Growth Across the Lifespan.Nutrients · 2026Article
- Intranasal pramlintide matches intraperitoneal effects on food intake and gastric emptying in mice.Endocrine · 2025Article
- Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity.eLife · 2023Article
- Evaluating the association between the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, mental health, and cardio-metabolic risk factors among individuals with obesity.BMC endocrine disorders · 2023Article
- TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons.The Journal of clinical investigation · 2022Article
- Brain circuits for promoting homeostatic and non-homeostatic appetites.Experimental & molecular medicine · 2022Review
- Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward autoactivation loop in mice.The Journal of clinical investigation · 2021Article
- Neuropeptidergic Control of Feeding: Focus on the Galanin Family of Peptides.International journal of molecular sciences · 2021Review
- Paraventricular hypothalamus mediates diurnal rhythm of metabolism.Nature communications · 2020Article
- The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats.Scientific reports · 2019Article
- Defining the caudal hypothalamic arcuate nucleus with a focus on anorexic excitatory neurons.The Journal of physiology · 2019Article
- Melanocortin neurons: Multiple routes to regulation of metabolism.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Heparin Increases Food Intake through AgRP Neurons.Cell reports · 2017Article
- The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.The Journal of biological chemistry · 2017Article
- Agouti Related Peptide Secreted Via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer's Disease Model.Scientific reports · 2017Article
- Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome.Disease models & mechanisms · 2016Article
- The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis.Molecular metabolism · 2015Article
- Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states.Frontiers in systems neuroscience · 2015Review
- Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.Molecular metabolism · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The current obesity epidemic and lack of efficient therapeutics demand a clear understanding of the mechanism underlying body weight regulation. Despite intensive research focus on obesity pathogenesis, an effective therapeutic strategy to treat and cure obesity is still lacking. Exciting studies in last decades have established the importance of hypothalamic agouti-related protein-expressing neurons (AgRP neurons) in the regulation of body weight homeostasis. AgRP neurons are both required and sufficient for feeding regulation. The activity of AgRP neurons is intricately regulated by nutritional hormones as well as synaptic inputs from upstream neurons. Changes in AgRP neuron activity lead to alterations in the release of mediators, including neuropeptides Neuropeptide Y (NPY) and AgRP, and fast-acting neurotransmitter GABA. Recent studies based on mouse genetics, novel optogenetics, and designer receptor exclusively activated by designer drugs have identified a critical role for GABA release from AgRP neurons in the parabrachial nucleus and paraventricular hypothalamus in feeding control. This review will summarize recent findings about AgRP neuron-mediated control of feeding circuits with a focus on the role of neurotransmitters. Given the limited knowledge on feeding regulation, understanding the action of neurotransmitters may be a key to unlock neurocircuitry that governs feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.