ArticleJournal of biological physics2005
How nature modulates inherent fluctuations for biological self-organization - the case of membrane fusion.
Article in Journal of biological physics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Hierarchical Order Parameters for Macromolecular Assembly Simulations I: Construction and Dynamical Properties of Order Parameters.Journal of chemical theory and computation · 2012Article
- Multiscale simulation of microbe structure and dynamics.Progress in biophysics and molecular biology · 2011Article
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Authors and funding
2 authors.
Funding
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Abstract
Biological systems in nano-scale, due to the weak electrostatic interactions and structural connectivity therein, are flexible so that they undergo conformational transition subject to thermal fluctuations and external noises. In the presence of barriers, nature utilizes the fluctuations to give rise to self-organization, typically accompanied by conformational transitions. In two opposing membranes with like-charges, the cooperative coupling between the undulation and charge fluctuations give rise to a dynamic instability to spontaneous growth of the in-phase membrane undulation, and thus a great reduction of the energy barrier to fusion. The multivalent counter-ions, the Ca(2+) for example, enhance the necessary charge density fluctuation leading to surface charge inversion and overcondensation.
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