ArticleJournal of biological physics2005
Mathematical modelling of ca(2+) oscillations in airway smooth muscle cells.
Article in Journal of biological physics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Interdependence of cytosolic and mitochondrial calcium dynamics in a hepatocyte cell due to obesity.Journal of biosciences · 2026Article
- Numerical simulation of calcium dynamics dependent ATP degradation, IPJournal of biological physics · 2023Article
- Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- A deterministic model predicts the properties of stochastic calcium oscillations in airway smooth muscle cells.PLoS computational biology · 2014Article
- Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model.PloS one · 2013Article
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Authors and funding
4 authors.
Funding
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Abstract
The action of different agonists such as acetylcholine on the membrane of airway smooth muscle cells may induce cytosolic Ca(2+) oscillations which can be a part of the Ca(2+) signalling pathway, eventually leading to cell contraction. The aim of the present study is to present a mathematical model of the possible effect of the initial Ca(2+) distribution within the cell on the form and frequency of induced Ca(2+) oscillations. It takes into account intracellular Ca(2+) stores such as sarcoplasmic reticulum and cytosolic proteins as well as Ca(2+) exchange across the plasma membrane. We are able to demonstrate a closer agreement of model predictions with observed Ca(2+) traces for a significantly wider range of parameter values, as was previously reported. We show also that the total cellular Ca(2+) content is an important system parameter especially because of the content in sarcoplasmic reticulum. At a total Ca(2+) increase of about 20%, the oscillation frequency increases by 25%; also, damped oscillations become sustained. Cases are indicated in which such a situation could occur.
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Registered trials
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