ArticleJournal of biological physics2005
Can we model DNA at the mesoscale?
Article in Journal of biological physics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Oncological hyperthermia: The correct dosing in clinical applications.International journal of oncology · 2019Article
- The relevance of nonlinear stacking interactions in simple models of double-stranded DNA.Journal of the Royal Society, Interface · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modelling DNA is useful for understanding its properties better but it is also challenging because many of these properties involve hundreds of base pairs or more, or time scales which are much longer than the time scales accessible to molecular dynamics. It is therefore necessary to develop models at a mesoscale, which include enough details to describe the properties of interest, for instance the biological sequence, while staying sufficiently simple and realistic.We discuss here two examples: a dynamical model to study the mechanical denaturation of DNA, which probes the sequence on various scales, and a model for the self assembly of DNA which describes the formation of hairpins and allows us to study its kinetics.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.