ArticleJournal of biological physics2004
Cell movements and mechanical force distribution during the migration of dictyostelium slugs.
Article in Journal of biological physics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Differential cell motion: A mathematical model of anterior posterior sorting.Biophysical journal · 2023Article
- Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum.Scientific reports · 2022Article
- Collective cell migration ofCommunications biology · 2019Article
- Local friction at a sliding interface between an elastomer and a rigid spherical probe.The European physical journal. E, Soft matter · 2008Article
- Calcium waves.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- An iterative method to calculate forces exerted by single cells and multicellular assemblies from the detection of deformations of flexible substrates.European biophysics journal : EBJ · 2006Article
- Direct mechanical force measurements during the migration of Dictyostelium slugs using flexible substrata.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migration of Dictyostelium discoideum slugs results from coordinated movement of their constituent cells. It is generally assumed that each cell contributes to the total motive force of the slug. However, the basic mechanisms by which mechanical forces (traction and resistive forces) are transmitted to the substrate, their magnitude and their location, are largely unknown. In this work, we performed detailed observations of cell movements by fluorescence microscopy using two-dimensional (2D) slugs. We show that 2D slugs share most of the properties of 3D ones. In particular, waves of movement propagate in long 2D slugs, and slug speed correlates with slug length as found in 3D slugs. We also present the first measurements of the distribution of forces exerted by 2D and 3D slugs using the elastic substrate method. Traction forces are mainly exerted in the central region of the slug. The large perpendicular forces around slug boundary and the existence of parallel resistive forces in the tip and/or the tail suggest an important role of the sheath in the transmission of forces to the substrate.
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Registered trials
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