ReviewOpen biology2013
Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for?
Review in Open biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- In vitro naive CD4Molecular biology reports · 2023Article
- IRF4 overexpression promotes the transdifferentiation of tregs into macrophage-like cells to inhibit the development of colon cancer.Cancer cell international · 2021Article
- Regulatory T Cell Plasticity and Stability and Autoimmune Diseases.Clinical reviews in allergy & immunology · 2020Review
- Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity.Frontiers in immunology · 2019Review
- Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility.Central-European journal of immunology · 2018Article
- IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.Scientific reports · 2017Article
- Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.Frontiers in cellular and infection microbiology · 2017Article
- Characteristics of Schistosoma japonicum infection induced IFN-γ and IL-4 co-expressing plasticity Th cells.Immunology · 2016Article
- Pathological conditions re-shape physiological Tregs into pathological Tregs.Burns & trauma · 2015Article
- Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets.Age (Dordrecht, Netherlands) · 2015Article
- IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.PLoS pathogens · 2015Article
- Translating transitions - how to decipher peripheral human B cell development.Journal of biomedical research · 2015Review
- Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive.PLoS pathogens · 2015Article
- CD4 T-cell subsets in malaria: TH1/TH2 revisited.Frontiers in immunology · 2014Review
- Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes.Current topics in microbiology and immunology · 2014Review
- Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets.Frontiers in immunology · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Following thymic output, αβ⁺CD4⁺ T cells become activated in the periphery when they encounter peptide-major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages and subsequent expansion and contraction during an appropriate and protective immune response. Our understanding of the events leading to T-cell lineage commitment has been dominated by a single fate model describing the commitment of T cells to one of several helper (T(H)), follicular helper (T(FH)) or regulatory (T(REG)) phenotypes. Although a single lineage-committed and dedicated T cell may best execute a single function, the view of a single fate for T cells has recently been challenged. A relatively new paradigm in αβ⁺CD4⁺ T-cell biology indicates that T cells are much more flexible than previously appreciated, with the ability to change between helper phenotypes, between helper and follicular helper, or, most extremely, between helper and regulatory functions. In this review, we comprehensively summarize the recent literature identifying when T(H) or T(REG) cell plasticity occurs, provide potential mechanisms of plasticity and ask if T-cell plasticity is beneficial or detrimental to immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.