ArticleProceedings of the National Academy of Sciences of the United States of America2013
Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
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Who cites it
96 citing papers in PubMed.
- Spatio-temporal multiscale cell modeling of skin wound healing.Biophysical journal · 2026Article
- Substrate heterogeneity promotes cancer cell dissemination through interface roughening.Science advances · 2026Article
- Multi-phase field model reveals internal dissipation is crucial for spontaneous hole formation in cell monolayers.Nature communications · 2026Article
- What is active wetting?The European physical journal. E, Soft matter · 2026Review
- Preliminary study of cyto-impedance: Molecular profiling of functional impedance in motility-promoting treatment of normal cells.Biochemistry and biophysics reports · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Statistical and mechanical analysis of multi-pseudopodial locomotion in a testate amoeba, Arcella sp.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026Article
- Modeling of viscous frictional force in multicellular morphogenesis.Biophysics and physicobiology · 2026Article
- Mechanoadaptive polysaccharide conjugates architect pro-healing microenvironments via dynamic stress redistribution in skin defects.Science advances · 2025Article
- Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function.Cell · 2025Review
- Traction and Stress Control Formation and Motion of +1/2 Topological Defects in Epithelial Cell Monolayers.Newton ((New York, N.Y.) · 2025Article
- Matrix-producing cells' orientation order facilitates Bacillus subtilis biofilm self-healing.Archives of microbiology · 2024Article
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- Mathematical modeling of evolution of cell networks in epithelial tissues.Quantitative biology (Beijing, China) · 2024Article
- Machine learning meets physics: A two-way street.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms.Soft matter · 2024Article
- Bridging the gap between collective motility and epithelial-mesenchymal transitions through the active finite voronoi model.Soft matter · 2023Article
- The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis.European journal of cell biology · 2023Article
- Generative models of morphogenesis in developmental biology.Seminars in cell & developmental biology · 2023Review
- Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis.PLoS computational biology · 2023Article
36 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent experiments have shown that spreading epithelial sheets exhibit a long-range coordination of motility forces that leads to a buildup of tension in the tissue, which may enhance cell division and the speed of wound healing. Furthermore, the edges of these epithelial sheets commonly show finger-like protrusions whereas the bulk often displays spontaneous swirls of motile cells. To explain these experimental observations, we propose a simple flocking-type mechanism, in which cells tend to align their motility forces with their velocity. Implementing this idea in a mechanical tissue simulation, the proposed model gives rise to efficient spreading and can explain the experimentally observed long-range alignment of motility forces in highly disordered patterns, as well as the buildup of tensile stress throughout the tissue. Our model also qualitatively reproduces the dependence of swirl size and swirl velocity on cell density reported in experiments and exhibits an undulation instability at the edge of the spreading tissue commonly observed in vivo. Finally, we study the dependence of colony spreading speed on important physical and biological parameters and derive simple scaling relations that show that coordination of motility forces leads to an improvement of the wound healing process for realistic tissue parameters.
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