ArticleProceedings of the National Academy of Sciences of the United States of America2013
Mechanism of action and initial evaluation of a membrane active all-D-enantiomer antimicrobial peptidomimetic.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 62 citations in OpenAlex.
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- Synergism of the Combination of Traditional Antibiotics and Novel Phenolic Compounds againstPathogens (Basel, Switzerland) · 2020Article
- In vitro synergistic potentials of novel antibacterial combination therapies against Salmonella enterica serovar Typhimurium.BMC microbiology · 2020Article
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- Adevonin, a novel synthetic antimicrobial peptide designed from the Adenanthera pavonina trypsin inhibitor (ApTI) sequence.Pathogens and global health · 2018Article
- Impact of phenolic compounds in the acyl homoserine lactone-mediated quorum sensing regulatory pathways.Scientific reports · 2017Article
- Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections.Advanced materials (Deerfield Beach, Fla.) · 2017Article
- Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria.PloS one · 2017Article
- Trojan Horse Antibiotics-A Novel Way to Circumvent Gram-Negative Bacterial Resistance?Infectious diseases · 2016Review
- In Vitro Activity of the Novel Antimicrobial Peptide Dendrimer G3KL against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa.Antimicrobial agents and chemotherapy · 2015Article
- Effects of transportation stress and addition of salt to transport water on the skin mucosal homeostasis of rainbow trout (Aquaculture (Amsterdam, Netherlands) · 2015Article
- Improved bioactivity of antimicrobial peptides by addition of amino-terminal copper and nickel (ATCUN) binding motifs.ChemMedChem · 2014Article
- Peptidomimetics as a new generation of antimicrobial agents: current progress.Infection and drug resistance · 2014Review
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Development of therapy against infections caused by antibiotic-resistant pathogens is a major unmet need in contemporary medicine. In previous work, our group chemically modified an antimicrobial peptidomimetic motif for targeted applications against cancer and obesity. Here, we show that the modified motif per se is resistant to proteolytic degradation and is a candidate antiinfective agent. We also show that the susceptibility of microorganisms to the drug is independent of bacterial growth phase. Moreover, this peptidomimetic selectively interferes with the integrity and function of the microbial surface lipid bilayer, data indicative that bacterial death results from membrane disruption followed by dissipation of membrane potential. Finally, we demonstrate two potential translational applications: use against biofilms and synergy with antibiotics in use. In summary, we introduce the mechanism of action and the initial evaluation of a prototype drug and a platform for the development of D-enantiomer antimicrobial peptidomimetics that target bacterial membranes of certain gram-negative problem pathogens with promising translational applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.