ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Selective ablation of pillar and deiters' cells severely affects cochlear postnatal development and hearing in mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 59 citations in OpenAlex.
- Type I hair cells of striolar and central zones in vestibular organs are essential for head stability and postural control.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hearing restoration through hair cell regeneration: A review of recent advancements and current limitations.Hearing research · 2025Review
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- Preservation of developmental spontaneous activity enables early auditory system maturation in deaf mice.PLoS biology · 2023Article
- Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Extracellular Vesicles in Inner Ear Therapies-Pathophysiological, Manufacturing, and Clinical Considerations.Journal of clinical medicine · 2022Review
- The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification.Journal of neurophysiology · 2022Article
- The regenerative capacity of neonatal tissues.Development (Cambridge, England) · 2022Review
- Lineage-tracing and translatomic analysis of damage-inducible mitotic cochlear progenitors identifies candidate genes regulating regeneration.PLoS biology · 2021Article
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- Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells.Frontiers in cellular neuroscience · 2021Article
- Axodendritic versus axosomatic cochlear efferent termination is determined by afferent type in a hierarchical logic of circuit formation.Science advances · 2021Article
- Deletion of Clusterin Protects Cochlear Hair Cells against Hair Cell Aging and Ototoxicity.Neural plasticity · 2021Article
- Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea.Scientific reports · 2020Article
- Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo.Clinical and translational medicine · 2020Article
- Perspectives on Human Hearing Loss, Cochlear Regeneration, and the Potential for Hearing Restoration Therapies.Brain sciences · 2020Review
- Dibenzazepine promotes cochlear supporting cell proliferation and hair cell regeneration in neonatal mice.Cell proliferation · 2020Article
- Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells.The EMBO journal · 2019Article
- OHC-TRECK: A Novel System Using a Mouse Model for Investigation of the Molecular Mechanisms Associated with Outer Hair Cell Death in the Inner Ear.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Mammalian auditory hair cells (HCs) are inserted into a well structured environment of supporting cells (SCs) and acellular matrices. It has been proposed that when HCs are irreversibly damaged by noise or ototoxic drugs, surrounding SCs seal the epithelial surface and likely extend the survival of auditory neurons. Because SCs are more resistant to damage than HCs, the effects of primary SC loss on HC survival and hearing have received little attention. We used the Cre/loxP system in mice to specifically ablate pillar cells (PCs) and Deiters' cells (DCs). In Prox1CreER(T2)+/-;Rosa26(DTA/+) (Prox1DTA) mice, Cre-estrogen receptor (CreER) expression is driven by the endogenous Prox1 promoter and, in presence of tamoxifen, removes a stop codon in the Rosa26(DTA/+) allele and induces diphtheria toxin fragment A (DTA) expression. DTA produces cell-autonomous apoptosis. Prox1DTA mice injected with tamoxifen at postnatal days 0 (P0) and P1 show significant DC and outer PC loss at P2-P4, that reaches ∼70% by 1 month. Outer HC loss follows at P14 and is almost complete at 1 month, while inner HCs remain intact. Neural innervation to the outer HCs is disrupted in Prox1DTA mice and auditory brainstem response thresholds in adults are 40-50 dB higher than in controls. The hearing deficit correlates with loss of cochlear amplification. Remarkably, in Prox1DTA mice, the auditory epithelium preserves the ability to seal the reticular lamina and spiral ganglion neuron counts are normal, a key requirement for cochlear implant success. In addition, our results show that cochlear SC pools should be appropriately replenished during HC regeneration strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.