ArticleMedical oncology (Northwood, London, England)2013
Association of LAPTM4B gene polymorphism with nasopharyngeal carcinoma susceptibility in a Chinese population.
Article in Medical oncology (Northwood, London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- LAPTM4B gene polymorphism augments the risk of cancer: Evidence from an updated meta-analysis.Journal of cellular and molecular medicine · 2018Pooled it
- LAPTM4B polymorphism increases susceptibility to multiple cancers in Chinese populations: a meta-analysis.BMC genetics · 2014Pooled it
- The role and regulatory mechanism of lysosome associated protein transmembrane 4β in tumors.Frontiers in oncology · 2025Review
- Role and mechanism of action of LAPTM4B in EGFR-mediated autophagy.Oncology letters · 2022Review
- Association betweenOncology letters · 2018Article
- LAPTM4B*2 allele is associated with the development of papillary thyroid carcinoma in Chinese women.Oncology letters · 2017Article
- Review
- Association betweenMolecular & cellular oncology · 2016Article
- The relationship between LAPTM4B polymorphisms and cancer risk in Chinese Han population: a meta-analysis.SpringerPlus · 2015Article
- Relationship Between LAPTM4B Gene Polymorphism and Susceptibility of Malignant Melanoma in Chinese Patients.Translational oncology · 2014Article
- Association between LAPTM4B gene polymorphism and breast cancer susceptibility in an Iranian population.Medical oncology (Northwood, London, England) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysosome-associated protein transmembrane-4 beta (LAPTM4B) is a novel cancer-related gene. It has two alleles designated LAPTM4B 1 and LAPTM4B 2. Previous studies have revealed that LAPTM4B polymorphisms contribute to the risk of many cancers. The aim of this study was to investigate the association between different LAPTM4B alleles and the risk of nasopharyngeal carcinoma (NPC), one of the most common cancers in southern China. Using polymerase chain reaction (PCR) in a case-control study, we detected the LAPTM4B genotype in peripheral blood samples from 134 patients with NPC and 327 control subjects. The chi-square test was used to analyze differences of categorical variables and Hardy-Weinberg equilibrium. Odds ratios and 95 % CI were computed using an unconditional logistic regression model. The frequency of allele 2 was 26.87 % in the NPC group, which was not significantly different from that of the control group (27.98 %, P = 0.867). Using the LAPTM4B 1/1 genotype as a reference, we found that the 1/2, 2/2 and 1/2 + 2/2 genotype were also not associated with the risk of NPC. No association was observed between LAPTM4B gene polymorphisms and the risk of NPC adjusted by gender and age. The results of our study indicated that the polymorphism of LAPTM4B gene did not influence the susceptibility of NPC in the Chinese population. Large-scale studies are needed to confirm our findings.
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