ArticleJournal of inherited metabolic disease2013
The CXCL12/CXCR4/CXCR7 ligand-receptor system regulates neuro-glio-vascular interactions and vessel growth during human brain development.
Article in Journal of inherited metabolic disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Diversified expression of NG2/CSPG4 isoforms in glioblastoma and human foetal brain identifies pericyte subsets.PloS one · 2013Trial
- Role of chemokines in early pregnancy loss.Experimental and therapeutic medicine · 2022Article
- Review
- Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas.Fluids and barriers of the CNS · 2021Review
- Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis.International journal of stem cells · 2021Article
- Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions.Cancers · 2020Review
- Involvement of CXCL12/CXCR4 in the motility of human first-trimester endometrial epithelial cells through an autocrine mechanism by activating PI3K/AKT signaling.BMC pregnancy and childbirth · 2020Article
- SDF1/CXCR4 axis plays a role in angiogenesis during the degeneration of intervertebral discs.Molecular medicine reports · 2019Article
- Tunneling nanotubes evoke pericyte/endothelial communication during normal and tumoral angiogenesis.Fluids and barriers of the CNS · 2018Article
- Glioma in Schizophrenia: Is the Risk Higher or Lower?Frontiers in cellular neuroscience · 2018Review
- CXCR7 Participates in CXCL12-mediated Cell Cycle and Proliferation Regulation in Mouse Neural Progenitor Cells.Current molecular medicine · 2016Article
- Nutrition and Vascular Supply of Retinal Ganglion Cells during Human Development.Frontiers in neurology · 2016Review
- Article
- SDF1-CXCR4 signaling contributes to persistent pain and hypersensitivity via regulating excitability of primary nociceptive neurons: involvement of ERK-dependent Nav1.8 up-regulation.Journal of neuroinflammation · 2015Article
- Radial glia, the keystone of the development of the hippocampal dentate gyrus.Molecular neurobiology · 2015Review
- An integrated assessment of histopathological changes of the enteric neuromuscular compartment in experimental colitis.Journal of cellular and molecular medicine · 2015Article
- Neurogenic niches in the brain: help and hindrance of the barrier systems.Frontiers in neuroscience · 2015Review
- Chemokine-ligands/receptors: multiplayers in traumatic spinal cord injury.Mediators of inflammation · 2015Review
- Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.International journal of endocrinology · 2014Review
- The contribution of CXCL12-expressing radial glia cells to neuro-vascular patterning during human cerebral cortex development.Frontiers in neuroscience · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
This study investigates glio-vascular interactions in human fetal brain at midgestation, specifically examining the expression and immunolocalization of the CXCL12/CXCR4/CXCR7 ligand-receptor axis and its possible role in the vascular patterning of the developing brain. At midgestation, the telencephalic vesicles are characterized by well developed radial glia cells (RGCs), the first differentiated astrocytes and a basic vascular network mainly built of radial vessels. RGCs have been recognized to contribute to cerebral cortex neuro-vascular architecture and have also been demonstrated to act as a significant source of neural cells (Rakic, Brain Res 33:471-476, 1971; Malatesta et al, Development 127:5253-5263, 2000). According to our hypothesis CXCL12, a potent migration and differentiation chemokine released by RGCs, may act as a linking factor coordinating neuroblast migration with vessel growth and patterning through the activation of different ligand/receptor axes. The obtained results support this hypothesis showing that together with CXCR4/CXCR7-reactive neuroblasts, which migrate in close association with CXCL12 RGCs, layer-specific subsets of CXCL12 RGCs and astrocytes specifically contact the microvessel wall. Moreover, the CXCL12/CXCR4/CXCR7 system appears to be directly involved in microvessel growth, its members being differentially expressed in angiogenically activated microvessels and vascular sprouts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.