ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2013
A ribonucleotide Origin for Life--fluctuation and near-ideal reactions.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Eighty routes to a ribonucleotide world; dispersion and stringency in the decisive selection.RNA (New York, N.Y.) · 2018Article
- Non-Watson-Crick RNA synthesis suited to origin functions.RNA (New York, N.Y.) · 2018Article
- Efficient Heritable Gene Expression Readily Evolves in RNA Pools.Journal of molecular evolution · 2017Article
- Biochemical Refinement Before Genetics: Chance Utility.Journal of molecular evolution · 2016Article
- Cross-backbone templating; ribodinucleotides made on poly(C).RNA (New York, N.Y.) · 2016Article
- Poly(U) RNA-templated synthesis of AppA.RNA (New York, N.Y.) · 2015Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligoribonucleotides are potentially capable of Darwinian evolution - they may replicate and can express an independent chemical phenotype, as embodied in modern enzymatic cofactors. Using quantitative chemical kinetics on a sporadically fed ribonucleotide pool, unreliable supplies of unstable activated ribonucleotides A and B at low concentrations recurrently yield a replicating AB polymer with a potential chemical phenotype. Self-complementary replication in the pool occurs during a minority (here ≈ 35 %) of synthetic episodes that exploit coincidental overlaps between 4, 5 or 6 spikes of arbitrarily arriving substrates. Such uniquely productive synthetic episodes, in which near-ideal reaction sequences recur at random, account for most AB oligonucleotide synthesis, and therefore underlie the emergence of net replication under realistic primordial conditions. Because overlapping substrate spikes are unexpectedly frequent, and in addition, complex spike sequences appear disproportionately, a sporadically fed pool can host unexpectedly complex syntheses. Thus, primordial substrate fluctuations are not necessarily a barrier to Darwinism, but instead can facilitate early evolution.
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