ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2013
Shenfu injection attenuates neonatal hypoxic-ischemic brain damage in rat.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 17 citations in OpenAlex.
- Shenfu Injection Protects Brain Injury in Rats with Cardiac Arrest through Nogo/NgR Pathway.Analytical cellular pathology (Amsterdam) · 2022Article
- lncRNA NEAT1 Binds to MiR-339-5p to Increase HOXA1 and Alleviate Ischemic Brain Damage in Neonatal Mice.Molecular therapy. Nucleic acids · 2020Article
- Effects of Shenfu Injection () on cerebral metabolism in a porcine model of cardiac arrest.Chinese journal of integrative medicine · 2017Article
- Effects of Shenfu Injection in the Treatment of Septic Shock Patients: A Multicenter, Controlled, Randomized, Open-Label Trial.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Neuroprotective effect of Shenfu Injection () following cardiac arrest in pig correlates with improved mitochondrial function and cerebral glucose uptake.Chinese journal of integrative medicine · 2014Article
- Perinatal neuroprotection.F1000prime reports · 2014Review
- Protective effect of shen-fu injection on neuronal mitochondrial function in a porcine model of prolonged cardiac arrest.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- The protective effects of Shen-Fu injection on experimental acute pancreatitis in a rat model.Oxidative medicine and cellular longevity · 2014Article
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4 authors at 3 institutions in 1 country.
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Abstract
Perinatal hypoxia-ischemia remains the most important cause of brain injury in the newborn. However, there is still no effective cure for neonatal hypoxic-ischemic brain damage (HIBD). In the present study, we aimed to examine the neuroprotective effects of Shenfu injection (SFI) on HIBD of neonatal rat. Sprague-Dawley rats were divided randomly into three groups (n = 8): S group: the rats were sham operated; C group: the rats were operated for HIBD modeling and received intraperitoneal injection of saline; SFI group: the rats were operated for HIBD modeling and received intraperitoneal injection of SFI (10 ml/kg days) for 7 days. Flow cytometry analysis showed that apoptosis rate of neuron in hippocampal CAI region in SFI group was significantly less than in NC group at 3 and 7 days after HI insult (P < 0.05). Immunohistochemical staining demonstrated that Bcl-2 expression was markedly higher while Bax expression was significantly lower in SFI group than in the C group at 24, 72 h and 7 days after HI insult (P < 0.05). Our findings suggest that SFI exhibits neuroprotective effects for neonatal hypoxic-ischemic brain injury by preventing neuron apoptosis and has potential to be used in the clinical for the treatment of perinatal hypoxia-ischemia.
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