Trial reportKidney international2013
Effect of frequent hemodialysis on residual kidney function.
Trial report in Kidney international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 88 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Frequent Hemodialysis Network: Daily Trial
Assessment of the Incremental Haemodialysis Security and Effectiveness in Incident Patients
Contribution of Body Composition Monitor (BCM) Among Patients Using Daily Home Dialysis With Low Dialysate Flow : French Study Cohort
NIRS: a Tool for the Diagnosis of Residual Renal Function Injury in Hemodialysis Patients
Who cites it
88 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Incremental Hemodialysis: Review of Clinical Trials Focused on Patients Undergoing Once-Weekly Hemodialysis.Nutrients · 2025Pooled it
- Peritoneal dialysis versus haemodialysis for people commencing dialysis.The Cochrane database of systematic reviews · 2024Pooled it
- Interventions for fatigue in people with kidney failure requiring dialysis.The Cochrane database of systematic reviews · 2023Pooled it
- Blood pressure and volume management in dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2020Guideline
- Renal Association Clinical Practice Guideline on Haemodialysis.BMC nephrology · 2019Guideline
- Pooled it
- Home versus in-centre haemodialysis for end-stage kidney disease.The Cochrane database of systematic reviews · 2014Pooled it
- Trial
- BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial.Health technology assessment (Winchester, England) · 2025Trial
- The Predialysis Serum Sodium Level Modifies the Effect of Hemodialysis Frequency on Left-Ventricular Mass: The Frequent Hemodialysis Network Trials.Kidney & blood pressure research · 2021Trial
- Association between change in serum bicarbonate and change in thyroid hormone levels in patients receiving conventional or more frequent maintenance haemodialysis.Nephrology (Carlton, Vic.) · 2019Trial
- Creatinine generation from kinetic modeling with or without postdialysis serum creatinine measurement: results from the HEMO study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Trial
- A Trial of Extending Hemodialysis Hours and Quality of Life.Journal of the American Society of Nephrology : JASN · 2017Trial
- Long-Term Effects of Frequent In-Center Hemodialysis.Journal of the American Society of Nephrology : JASN · 2016Trial
- Long-term Effects of Frequent Nocturnal Hemodialysis on Mortality: The Frequent Hemodialysis Network (FHN) Nocturnal Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Trial
- Effects of frequent hemodialysis on perceived caregiver burden in the Frequent Hemodialysis Network trials.Clinical journal of the American Society of Nephrology : CJASN · 2014Trial
- Agreement of single- and multi-frequency bioimpedance measurements in hemodialysis patients: an ancillary study of the Frequent Hemodialysis Network Daily Trial.Nephron. Clinical practice · 2014Trial
- The hemodynamic cost of intermittent hemodialysis and systemic organ stunning.Renal failure · 2026Review
- Hypertension in Patients With End-Stage Kidney Disease Requiring Dialysis: Bridging the Divide Between Evidence and Practice.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Perspectives on Quality of Life, Vascular Access, and Fluid Balance in Incremental Hemodialysis: A Narrative Review.Kidney360 · 2026Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
12 authors.
Funding
Abstract
Frequent hemodialysis can alter volume status, blood pressure, and the concentration of osmotically active solutes, each of which might affect residual kidney function (RKF). In the Frequent Hemodialysis Network Daily and Nocturnal Trials, we examined the effects of assignment to six compared with three-times-per-week hemodialysis on follow-up RKF. In both trials, baseline RKF was inversely correlated with number of years since onset of ESRD. In the Nocturnal Trial, 63 participants had non-zero RKF at baseline (mean urine volume 0.76 liter/day, urea clearance 2.3 ml/min, and creatinine clearance 4.7 ml/min). In those assigned to frequent nocturnal dialysis, these indices were all significantly lower at month 4 and were mostly so at month 12 compared with controls. In the frequent dialysis group, urine volume had declined to zero in 52% and 67% of patients at months 4 and 12, respectively, compared with 18% and 36% in controls. In the Daily Trial, 83 patients had non-zero RKF at baseline (mean urine volume 0.43 liter/day, urea clearance 1.2 ml/min, and creatinine clearance 2.7 ml/min). Here, treatment assignment did not significantly influence follow-up levels of the measured indices, although the range in baseline RKF was narrower, potentially limiting power to detect differences. Thus, frequent nocturnal hemodialysis appears to promote a more rapid loss of RKF, the mechanism of which remains to be determined. Whether RKF also declines with frequent daily treatment could not be determined.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.