ArticleMarine drugs2013
Isolation and purification of a peptide from Bullacta exarata and its impaction of apoptosis on prostate cancer cell.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Marine life as a source of anti-prostate cancer agents: an updated overview (2003-2023).Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Antioxidant and antiproliferative activity of enzymatic hydrolysates from red tilapia (Biotechnology reports (Amsterdam, Netherlands) · 2024Article
- Natural Anticancer Peptides from Marine Animal Species: Evidence from In Vitro Cell Model Systems.Cancers · 2023Review
- Optimization of the Red Tilapia (Foods (Basel, Switzerland) · 2020Article
- Effects of preparation method on the biochemical characterization and cytotoxic activity of New Zealand surf clam extracts.Heliyon · 2020Article
- A novel anti‑proliferative pentapeptide (ILYMP) isolated from Cyclina sinensis protein hydrolysate induces apoptosis of DU‑145 prostate cancer cells.Molecular medicine reports · 2018Article
- Anticancer Activity of Anthopleura anjunae Oligopeptides in Prostate Cancer DU-145 Cells.Marine drugs · 2018Article
- A Purified Serine Protease from Nereis virens and Its Impaction of Apoptosis on Human Lung Cancer Cells.Molecules (Basel, Switzerland) · 2017Article
- Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review.British journal of pharmacology · 2017Review
- Sepia ink oligopeptide induces apoptosis and growth inhibition in human lung cancer cells.Oncotarget · 2017Article
- A Novel Polysaccharide Conjugate from Bullacta exarata Induces G1-Phase Arrest and Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells.Molecules (Basel, Switzerland) · 2017Article
- Anticancer Activity of a Hexapeptide from Skate (Raja porosa) Cartilage Protein Hydrolysate in HeLa Cells.Marine drugs · 2016Article
- Marine Peptides: Bioactivities and Applications.Marine drugs · 2015Review
- From antimicrobial to anticancer peptides. A review.Frontiers in microbiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Bullacta exarata was hydrolyzed with trypsin to prepare peptides; Hydrolysates were isolated by ultrafiltration and purified using G-25 gel filtration. The purity of the Bullacta exarata was demonstrated by HPLC and its peptide sequence analysis was detected. The effects of BEPT II and BEPT II-1 on the proliferation of PC-3 cells were examined using a MTT assay. BEPT II and BEPT II-1 significantly inhibited the proliferation of PC-3 cells in a time- and dose-dependent manner. Annexin V/PI double staining studies showed exposing PC-3 cells to 5, or 15 mg/mL BEPT II-1 for 24 h increased the percentage of the early stage of apoptotic cells from 11.22% to 22.09%. In addition, typical morphologic changes were observed in the cells with acridine orange/ethidium bromide staining. These data support that BEPT II-1 has anticancer properties and merits further investigation to understand the mechanisms of BEPT II-1-induced apoptosis in PC-3 cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.