ArticleMarine drugs2013
Quorum sensing inhibition by Asparagopsis taxiformis, a marine macro alga: separation of the compound that interrupts bacterial communication.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 95 citations in OpenAlex.
- Therapeutic investigation of Jania rubens polysaccharides: antimicrobial activity and potentiation of chemotherapy in colorectal cancer cells.BMC complementary medicine and therapies · 2026Article
- A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean.Communications biology · 2025Review
- A comprehensive review on microbial diversity and anticancer compounds derived from seaweed endophytes: a pharmacokinetic and pharmacodynamic approach.Archives of microbiology · 2024Review
- Anti-biofilm activity of marine algae-derived bioactive compounds.Frontiers in microbiology · 2024Review
- Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms.BioMed research international · 2023Review
- Review
- Mining for Active Molecules in Probiotic Supernatant by Combining Non-Targeted Metabolomics and Immunoregulation Testing.Metabolites · 2022Article
- Effects of wind-wave disturbance and nutrient addition on aquatic bacterial diversity, community composition, and co-occurrence patterns: A mesocosm study.Current research in microbial sciences · 2022Article
- Quorum Sensing Inhibitors: Curbing Pathogenic Infections through Inhibition of Bacterial Communication.Iranian journal of pharmaceutical research : IJPR · 2021Review
- Ecological and Industrial Implications of Dynamic Seaweed-Associated Microbiota Interactions.Marine drugs · 2020Review
- Quorum Quenching: A Potential Target for Antipseudomonal Therapy.Infection and drug resistance · 2020Review
- Antimicrobial and Anti-Quorum Sensing Activities of Phlorotannins From Seaweed (Frontiers in cellular and infection microbiology · 2020Article
- From Ecology to Biotechnology, Study of the Defense Strategies of Algae and Halophytes (from Trapani Saltworks, NW Sicily) with a Focus on Antioxidants and Antimicrobial Properties.International journal of molecular sciences · 2019Article
- Minireview: algal natural compounds and extracts as antifoulants.Journal of applied phycology · 2018Review
- Review
- Antifouling Compounds from Marine Macroalgae.Marine drugs · 2017Review
- Bioactive Potential of Marine Macroalgae from the Central Red Sea (Saudi Arabia) Assessed by High-Throughput Imaging-Based Phenotypic Profiling.Marine drugs · 2017Article
- Quorum Sensing Inhibitors from the Sea Discovered Using Bacterial N-acyl-homoserine Lactone-Based Biosensors.Marine drugs · 2017Review
- The role of chemical antifouling defence in the invasion success of Sargassum muticum: A comparison of native and invasive brown algae.PloS one · 2017Article
- Quorum sensing is a language of chemical signals and plays an ecological role in algal-bacterial interactions.Critical reviews in plant sciences · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of the marine algal species, though completing their life cycle in seawater, are rarely susceptible to fouling, making them an important source of quorum sensing (QS) inhibitory substances. The separation and characterization of QS inhibitors are crucial for any potential application. Thirty marine macroalgae were tested for QS inhibition activity by using Chromobacterium violaceum CV026 as the reporter strain, and among them, Asparagopsis taxiformis showed antibacterial, as well as antiquorum, sensing activities. Cinnamaldehyde (75 mM) and methanol were used as positive and negative controls, respectively. The antiquorum sensing activity of A. taxiformis was further confirmed using the sensor strain, Serratia liquefaciens MG44, having green fluorescent protein (gfp). Methanolic extract of the alga was fractionated by solid phase extraction (SPE), and each fraction was tested for QS inhibition. Two types of activities were observed-zone of clearance (antibacterial activity) and zone of inhibition with or without finger-like projections (QS inhibition). Out of five SPE cartridges, Bond Elut PH showed clear separation of these two fractions. The Ion Cyclotron Resonance Fourier Transformation Mass Spectrometer (ICR-FT/MS) analysis of the fractions further supported the bioassay results. The presence of strong QS inhibitory compound in A. taxiformis indicates its potential use in antifouling preparations.
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