ReviewInternational journal of molecular sciences2012
Spatial regulation of epidermal growth factor receptor signaling by endocytosis.
Review in International journal of molecular sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling.eLife · 2025Article
- Piezo1 activates noncanonical EGFR endocytosis and signaling.Science advances · 2023Article
- Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation.Nature communications · 2022Article
- Review
- Dynamics of Endocytosis and Degradation of Antibody-Drug Conjugate T-DM1 in HER2 Positive Cancer Cells.Drug design, development and therapy · 2021Article
- HCMV-induced signaling through gB-EGFR engagement is required for viral trafficking and nuclear translocation in primary human monocytes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Femtosecond Plasmonic Laser Nanosurgery (fs-PLN) mediated by molecularly targeted gold nanospheres at ultra-low pulse fluences.Scientific reports · 2020Article
- Article
- Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.Analytical cellular pathology (Amsterdam) · 2020Article
- Membrane-bound estrogen receptor alpha initiated signaling is dynamin dependent in breast cancer cells.European journal of medical research · 2018Article
- Nanoparticle-cell interactions induced apoptosis: a case study with nanoconjugated epidermal growth factor.Nanoscale · 2018Article
- Revisiting Netrin-1: One Who Guides (Axons).Frontiers in cellular neuroscience · 2018Review
- Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell.The Journal of cell biology · 2017Review
- Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy.ACS nano · 2017Article
- Quantum dots implementation as a label for analysis of early stages of EGF receptor endocytosis: a comparative study on cultured cells.Oncotarget · 2016Article
- Article
- Antagonizing c-Cbl enhances EGFR-dependent corneal epithelial homeostasis.Investigative ophthalmology & visual science · 2014Article
- Editorial of the special issue: signaling molecules and signal transduction in cells.International journal of molecular sciences · 2013Article
- MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation.International journal of molecular sciences · 2013Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Signaling by cell surface receptors appears to be relatively straight-forward: ligand binds to the extracellular domain of the receptor and biochemical changes are communicated into the cell. However, this process is more complex than it first seems due to the various mechanisms that regulate signaling. In order to effectively target these receptors for pharmacological purposes, a more complete understanding of how their signaling is regulated is needed. Here, how the endocytic pathway regulates receptor signaling is discussed, using the epidermal growth factor receptor (EGFR) as a model. In particular, the spatial regulation of signaling is examined. Areas of discussion include: how endocytic trafficking affects biology/pathology, varying approaches for studying the relationship between receptor endocytosis and signaling, and developments in how the endocytic pathway controls EGFR:effector communication and EGFR-mediated cell biology.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.