ArticleJournal of neurophysiology2013
Augmented P2X response and immunolabeling in dorsal root ganglion neurons innervating skeletal muscle following femoral artery occlusion.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Muscle afferent ASIC3 upregulation mediates the exacerbated exercise pressor reflex in male rats following hindlimb ischemia-reperfusion.Physiological reports · 2025Article
- Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats.The Journal of physiology · 2023Article
- Bradykinin 2 receptors contribute to the exaggerated exercise pressor reflex in a rat model of simulated peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Sympathetic Nerve Activity and Blood Pressure Response to Exercise in Peripheral Artery Disease: From Molecular Mechanisms, Human Studies, to Intervention Strategy Development.International journal of molecular sciences · 2022Review
- Gene and protein expression of dorsal root ganglion sensory receptors in normotensive and hypertensive male rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- ASIC3 knockout alters expression and activity of P2X3 in muscle afferent nerves of rat model of peripheral artery disease.FASEB bioAdvances · 2022Article
- Assessment relationship between the femoral artery vasospasm and dorsal root ganglion cell degeneration in spinal subarachnoid hemorrhage: an experimental study.Spinal cord · 2022Article
- Exaggerated blood pressure response to static exercise in hindlimb ischemia-reperfusion.Frontiers in physiology · 2022Article
- Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function.Neural regeneration research · 2021Article
- HIF-1α inhibition alleviates the exaggerated exercise pressor reflex in rats with peripheral artery disease induced by femoral artery occlusion.Physiological reports · 2021Article
- Heat treatment improves the exaggerated exercise pressor reflex in rats with femoral artery occlusion via a reduction in the activity of the P2X receptor pathway.The Journal of physiology · 2020Article
- One-Time Acute Heat Treatment Is Effective for Attenuation of the Exaggerated Exercise Pressor Reflex in Rats With Femoral Artery Occlusion.Frontiers in physiology · 2020Article
- The role played by oxidative stress in evoking the exercise pressor reflex in health and simulated peripheral artery disease.The Journal of physiology · 2017Article
- Purinergic P2X Receptors and Heightened Exercise Pressor Reflex in Peripheral Artery Disease.Internal medicine review (Washington, D.C. : Online) · 2016Article
- Bradykinin Contributes to Sympathetic and Pressor Responses Evoked by Activation of Skeletal Muscle Afferents P2X in Heart Failure.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2016Article
- Combined, but not individual, blockade of ASIC3, P2X, and EP4 receptors attenuates the exercise pressor reflex in rats with freely perfused hindlimb muscles.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- The exercise pressor reflex and peripheral artery disease.Autonomic neuroscience : basic & clinical · 2015Review
- TRPA1 mediates amplified sympathetic responsiveness to activation of metabolically sensitive muscle afferents in rats with femoral artery occlusion.Frontiers in physiology · 2015Article
- Purinergic 2X receptors play a role in evoking the exercise pressor reflex in rats with peripheral artery insufficiency.American journal of physiology. Heart and circulatory physiology · 2014Article
- Nerve Growth Factor, Muscle Afferent Receptors and Autonomic Responsiveness with Femoral Artery Occlusion.Journal of modern physiological research · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The responsiveness of sensory neurons to muscle metabolites is altered under the conditions of insufficient limb blood supply in some diseases, such as peripheral artery disease. The purpose of this study was to examine ATP-induced current with activation of purinergic P2X subtypes P2X₃ and P2X₂/₃ in dorsal root ganglion (DRG) neurons of control limbs and limbs with 24 h of femoral artery occlusion using whole cell patch-clamp methods. Also, dual-labeling immunohistochemistry was employed to determine existence of P2X₃ expression in DRG neurons of thin-fiber afferents. DRG neurons from 4- to 6-wk-old rats were labeled by injecting the fluorescence tracer DiI into the hindlimb muscles 4-5 days before the recording experiments. Transient (P2X₃), mixed (P2X₃ and P2X₂/₃), and sustained (P2X₂/₃) current responses to α,β-methylene ATP (a P2X receptor agonist) are observed in small and medium DRG neurons, and size distribution of DRG neurons is similar in control and occluded limbs. However, the peak current amplitude of DRG neuron induced by stimulation of P2X₃ and/or P2X₂/₃ is larger in occluded limbs than that in control limbs. Moreover, the percentage of DRG neurons with P2X₃ transient currents is greater after arterial occlusion compared with control. In addition, a rapid desensitization was observed in DRG neurons with transient currents, but not with sustained currents in control and occluded groups. Furthermore, results from immunofluorescence experiments show that femoral artery occlusion primarily augments P2X₃ expression within DRG neurons projecting C-fiber afferents. Overall, these findings suggest that 1) greater ATP-induced currents with activation of P2X₃ and P2X₂/₃ are developed when hindlimb arterial blood supply is deficient under ischemic conditions and 2) increased P2X₃ expression is largely observed in C-fibers of DRG neurons after hindlimb vascular insufficiency.
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