ArticleJournal of neurophysiology2013
Extrasynaptic glutamate and inhibitory neurotransmission modulate ganglion cell participation during glutamatergic retinal waves.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease.International journal of molecular sciences · 2024Review
- Building a circuit through correlated spontaneous neuronal activity in the developing vertebrate and invertebrate visual systems.Genes & development · 2021Review
- Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors.Cell reports · 2019Article
- Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors.Nature communications · 2016Article
- Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Spatiotemporal Features of Retinal Waves Instruct the Wiring of the Visual Circuitry.Frontiers in neural circuits · 2016Review
- Glutamatergic Retinal Waves.Frontiers in neural circuits · 2016Review
- Increasing Spontaneous Retinal Activity before Eye Opening Accelerates the Development of Geniculate Receptive Fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Spontaneous Neurotransmitter Release Shapes Dendritic Arbors via Long-Range Activation of NMDA Receptors.Cell reports · 2015Article
- Elucidating the role of AII amacrine cells in glutamatergic retinal waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- CaV3.2 KO mice have altered retinal waves but normal direction selectivity.Visual neuroscience · 2015Article
- A reaction-diffusion model of cholinergic retinal waves.PLoS computational biology · 2014Article
- Copper is an endogenous modulator of neural circuit spontaneous activity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The role of neuronal activity and transmitter release on synapse formation.Current opinion in neurobiology · 2014Review
- Single-cell imaging tools for brain energy metabolism: a review.Neurophotonics · 2014Article
- Spontaneous Network Activity and Synaptic Development.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
During the first 2 wk of mouse postnatal development, transient retinal circuits give rise to the spontaneous initiation and lateral propagation of depolarizations across the ganglion cell layer (GCL). Glutamatergic retinal waves occur during the second postnatal week, when GCL depolarizations are mediated by ionotropic glutamate receptors. Bipolar cells are the primary source of glutamate in the inner retina, indicating that the propagation of waves depends on their activation. Using the fluorescence resonance energy transfer-based optical sensor of glutamate FLII81E-1μ, we found that retinal waves are accompanied by a large transient increase in extrasynaptic glutamate throughout the inner plexiform layer. Using two-photon Ca(2+) imaging to record spontaneous Ca(2+) transients in large populations of cells, we found that despite this spatially diffuse source of depolarization, only a subset of neurons in the GCL and inner nuclear layer (INL) are robustly depolarized during retinal waves. Application of the glutamate transporter blocker dl-threo-β-benzyloxyaspartate (25 μM) led to a significant increase in cell participation in both layers, indicating that the concentration of extrasynaptic glutamate affects cell participation in both the INL and GCL. In contrast, blocking inhibitory transmission with the GABAA receptor antagonist gabazine and the glycine receptor antagonist strychnine increased cell participation in the GCL without significantly affecting the INL. These data indicate that during development, glutamate spillover provides a spatially diffuse source of depolarization, but that inhibitory circuits dictate which neurons within the GCL participate in retinal waves.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.