Evidence map›Paper›PMID 23343892›Full record

ArticleJournal of neurophysiology2013

Intrinsic physiological properties of the five types of mouse ganglion-cell photoreceptors.

Caiping Hu, Dijon D Hill, Kwoon Y Wong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 70 citations in OpenAlex.

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  15. Degeneration of ipRGCs in Mouse Models of Huntington's Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  16. Article
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  18. [Changes of membrane properties and synaptic stability of rat retinal ganglion cells during postnatal development].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Caiping HuDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, USA.
Dijon D Hill
Kwoon Y Wong
University of Michigan–Ann Arbor · US

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Cross-talk between ganglion-cell photoreceptors and other neurons in the retinaR00EY018863 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WONG, KWOON Y. · 2010 to 2012
$700k
NEI NIH HHS P30 EY007003NEI NIH HHS R00 EY018863NEI NIH HHS R00 EY18863
6 · The paper itself

Abstract

In the mammalian retina, some ganglion cells express the photopigment melanopsin and function as photoreceptors. Five morphological types of these intrinsically photosensitive retinal ganglion cells (ipRGCs), M1-M5, have been identified in mice. Whereas M1 specializes in non-image-forming visual functions and drives such behaviors as the pupillary light reflex and circadian photoentrainment, the other types appear to contribute to image-forming as well as non-image-forming vision. Recent work has begun to reveal physiological diversity among some of the ipRGC types, including differences in photosensitivity, firing rate, and membrane resistance. To gain further insights into these neurons' functional differences, we conducted a comprehensive survey of the electrophysiological properties of all five morphological types. Compared with the other types, M1 had the highest membrane resistance, longest membrane time constant, lowest spike frequencies, widest action potentials, most positive spike thresholds, smallest hyperpolarization-activated inwardly-rectifying current-induced "sagging" responses to hyperpolarizing currents, and the largest effects of voltage-gated K(+) currents on membrane potentials. M4 and M5 were at the other end of the spectrum for most of these measures, while M2 and M3 tended to be in the middle of this spectrum. Additionally, M1 and M2 cells generated more diverse voltage-gated Ca(2+) currents than M3-M5. In conclusion, M1 cells are significantly different from all other ipRGCs in most respects, possibly reflecting the unique physiological requirements of non-image-forming vision. Furthermore, the non-M1 ipRGCs are electrophysiologically heterogeneous, implicating these cells' diverse functional roles in both non-image-forming vision and pattern vision.

Indexed as

Action PotentialsAnimalsCalcium ChannelsMembrane PotentialsMicePhotoreceptor Cells, VertebratePotassium Channels, Voltage-GatedRetinal Ganglion CellsCalcium ChannelsPotassium Channels, Voltage-Gated

Identifiers

PMID23343892
PMCPMC3628016
OpenAlexW2067508742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.