ArticleJournal of neurophysiology2013
Responses to pulsatile subretinal electric stimulation: effects of amplitude and duration.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Multiple consecutive-biphasic pulse stimulation improves spatially localized firing of retinal ganglion cells in the degenerate retina.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
- High amplitude pulses on the same charge condition efficiently elicit bipolar cell-mediated retinal ganglion cell responses in the degenerate retina.Biomedical engineering letters · 2023Article
- Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2022Article
- Electrical response of retinal ganglion cells in an N-methyl-N-nitrosourea-induced retinal degeneration porcine model.Scientific reports · 2021Article
- The impact of synchronous versus asynchronous electrical stimulation in artificial vision.Journal of neural engineering · 2021Review
- Article
- Computational challenges and opportunities for a bi-directional artificial retina.Journal of neural engineering · 2020Article
- Retinal Degeneration Reduces Consistency of Network-Mediated Responses Arising in Ganglion Cells to Electric Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2020Article
- Noninvasive Electrical Stimulation Improves Photoreceptor Survival and Retinal Function in Mice with Inherited Photoreceptor Degeneration.Investigative ophthalmology & visual science · 2020Article
- Response of Mouse Visual Cortical Neurons to Electric Stimulation of the Retina.Frontiers in neuroscience · 2019Article
- Electric stimulus duration alters network-mediated responses depending on retinal ganglion cell type.Journal of neural engineering · 2018Article
- Optimization of Stimulation Parameters for Targeted Activation of Multiple Neurons Using Closed-Loop Search Methods.Processes (Basel, Switzerland) · 2017Article
- The advantage of topographic prominence-adopted filter for the detection of short-latency spikes of retinal ganglion cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Differential effect of brief electrical stimulation on voltage-gated potassium channels.Journal of neurophysiology · 2017Article
- Implantable microcoils for intracortical magnetic stimulation.Science advances · 2016Article
- Electronic approaches to restoration of sight.Reports on progress in physics. Physical Society (Great Britain) · 2016Review
- Temporal properties of network-mediated responses to repetitive stimuli are dependent upon retinal ganglion cell type.Journal of neural engineering · 2016Article
- The Retinal Response to Sinusoidal Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2016Article
- Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration.Science translational medicine · 2015Article
- Indirect activation elicits strong correlations between light and electrical responses in ON but not OFF retinal ganglion cells.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In working to improve the quality of visual percepts elicited by retinal prosthetics, considerable effort has been made to understand how retinal neurons respond to electric stimulation. Whereas responses arising from direct activation of retinal ganglion cells have been well studied, responses arising through indirect activation (e.g., secondary to activation of bipolar cells) are not as well understood. Here, we used cell-attached, patch-clamp recordings to measure the responses of rabbit ganglion cells in vitro to a wide range of stimulus-pulse parameters (amplitudes: 0-100 μA; durations: 0.1-50 ms), applied to a 400-μm-diameter, subretinal-stimulating electrode. The indirect responses generally consisted of multiple action potentials that were clustered into bursts, although the latency and number of spikes within a burst were highly variable. When different parameter pairs representing identical charge levels were compared, the shortest pulse durations generally elicited the most spikes. In addition, latencies were shortest, and jitter was lowest for short pulses. These findings suggest that short pulses are optimum for activation of presynaptic neurons, and therefore, short pulses are more effective for both direct as well as indirect activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.