Evidence map›Paper›PMID 23343859›Full record

SynthesisOccupational and environmental medicine2013

Work activities and risk of prematurity, low birth weight and pre-eclampsia: an updated review with meta-analysis.

Keith T Palmer, Matteo Bonzini, E Clare Harris, Cathy Linaker, Jens Peter Bonde

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in Occupational and environmental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. The consequences of a compressed workweek: a systematic literature review.International archives of occupational and environmental health · 2025
    Pooled it
  2. Pooled it
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  10. Reproductive disorders among cosmetologists and hairdressers: a meta-analysis.International archives of occupational and environmental health · 2016
    Pooled it
  11. Review
  12. Article
  13. Article
  14. Article
  15. Is Sitting Really the New Smoking? Health of North American Workers Exposed to Prolonged Static Standing.New solutions : a journal of environmental and occupational health policy : NS · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Keith T PalmerMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK. ktp@mrc.soton.ac.uk
Matteo Bonzini
E Clare Harris
Cathy Linaker
Jens Peter Bonde

Funding

Medical Research Council MC_UP_A620_1018
6 · The paper itself

Abstract

objectivesWe assessed the evidence relating preterm delivery (PTD), low birth weight, small for gestational age (SGA), pre-eclampsia and gestational hypertension to five occupational exposures (working hours, shift work, lifting, standing and physical workload). We conducted a systematic search in Medline and Embase (1966 to 2011), updating a previous search with a further 6 years of observations.

methodsAs before, combinations of keywords and medical subject headings were used. Each relevant paper was assessed for completeness of reporting and potential for important bias or confounding, and its effect estimates abstracted. Where similar definitions of exposure and outcome existed we calculated pooled estimates of relative risk (RR) in meta-analysis.

resultsAnalysis was based on 86 reports (32 cohort investigations, 57 with usable data on PTD, 54 on birth weight and 11 on pre-eclampsia/gestational hypertension); 33 reports were new to this review. For PTD, findings across a substantial evidence base were generally consistent, effectively ruling out large effects (eg, RR>1.2). Larger and higher quality studies were less positive, while meta-estimates of risk were smaller than in previous analyses and best estimates pointed to modest or null effects (RR 1.04 to 1.18). For SGA, the position was similar but meta-estimates were even closer to the null (eight of nine RRs ≤ 1.07). For pre-eclampsia/gestational hypertension the evidence base remains insufficient.

conclusionsThe balance of evidence is against large effects for the associations investigated. As the evidence base has grown, estimates of risk in relation to these outcomes have become smaller.

Indexed as

Infant, PrematureInfant, Small for Gestational AgePregnancy OutcomeFemaleHumansHypertension, Pregnancy-InducedInfant, NewbornMaternal ExposureOccupational ExposurePre-EclampsiaPregnancyPremature BirthWeight-BearingWork Schedule Tolerance

Identifiers

PMID23343859
PMCPMC3653070

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.