SynthesisThe Journal of nutrition2013
Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.
Synthesis in The Journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes.PloS one · 2017Pooled it
- Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.The American journal of clinical nutrition · 2015Pooled it
- Dietary magnesium intake and metabolic syndrome in the adult population: dose-response meta-analysis and meta-regression.Nutrients · 2014Pooled it
- Serum Magnesium Concentrations in the United States-An Updated Population Reference Interval in Children and Adults.The Journal of nutrition · 2026Article
- Dietary magnesium, C-reactive protein and interleukin-6: The Strong Heart Family Study.PloS one · 2023Article
- Article
- Vitamin D, Calcium, Magnesium, and Potassium Consumption and Markers of Glucose Metabolism in the Hispanic Community Health Study/Study of Latinos.Journal of the American Nutrition Association · 2022Article
- The phenotypic and genetic spectrum of patients with heterozygous mutations in cyclin M2 (CNNM2).Human mutation · 2021Article
- Perspective: US Adult Magnesium Requirements Need Updating: Impacts of Rising Body Weights and Data-Derived Variance.Advances in nutrition (Bethesda, Md.) · 2021Article
- Magnesium and Hypertension in Old Age.Nutrients · 2020Review
- Article
- Calcium and vitamin DEuropean journal of nutrition · 2018Article
- From Neighborhood to Genome: Three Decades of Nutrition-Related Research from the Atherosclerosis Risk in Communities Study.Journal of the Academy of Nutrition and Dietetics · 2017Article
- The Rotterdam Study: 2018 update on objectives, design and main results.European journal of epidemiology · 2017Article
- Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome.Scientific reports · 2017Article
- Nutrient Patterns Associated with Fasting Glucose and Glycated Haemoglobin Levels in a Black South African Population.Nutrients · 2017Article
- The Importance of Magnesium in Clinical Healthcare.Scientifica · 2017Review
- Magnesium-permeableSpringerPlus · 2016Article
- The Rotterdam Study: 2016 objectives and design update.European journal of epidemiology · 2015Article
- Scientific Opinion on Dietary Reference Values for magnesium.EFSA journal. European Food Safety Authority · 2015Article
Corrections and comments
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Authors and funding
59 authors at 20 institutions in 7 countries.
Funding
Abstract
Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (ln-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [β = -0.009 mmol/L (95% CI: -0.013, -0.005), P < 0.0001] and insulin [-0.020 ln-pmol/L (95% CI: -0.024, -0.017), P < 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P = 0.03) with glucose, and rs11558471 in SLC30A8 and rs3740393 near CNNM2 showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted.
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