ArticleEarly intervention in psychiatry2014
Subtyping first-episode non-affective psychosis using four early-course features: potentially useful prognostic information at initial presentation.
Article in Early intervention in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Cognitive and clinical profiles in first-episode psychosis and their relationship with functional outcomes.The British journal of psychiatry : the journal of mental science · 2026Article
- Systematic review of pathways to care in the U.S. for Black individuals with early psychosis.NPJ schizophrenia · 2021Review
- A Synthetic Literature Review on the Management of Emerging Treatment Resistance in First Episode Psychosis: Can We Move towards Precision Intervention and Individualised Care?Medicina (Kaunas, Lithuania) · 2020Review
- Latent class cluster analysis of symptom ratings identifies distinct subgroups within the clinical high risk for psychosis syndrome.Schizophrenia research · 2018Article
- Early onset first episode psychosis: dimensional structure of symptoms, clinical subtypes and related neurodevelopmental markers.European child & adolescent psychiatry · 2018Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
aimHeterogeneity of symptoms, course and outcomes in primary psychotic disorders complicates prognosis, treatment and diverse aspects of research. This study aimed to identify interpretable subtypes of first-episode non-affective psychosis based on four early-course features (premorbid academic functioning, premorbid social functioning, duration of the prodrome and age at onset of psychosis).
methodsData from 200 well-characterized patients hospitalized in public-sector inpatient units for first-episode non-affective psychosis were used in latent profile analyses. Derived subtypes were then compared along a number of clinical dimensions using analyses of variance.
resultsUsing four early-course features, three classes were derived. A good premorbid/short prodrome subtype was characterized by a lower severity of positive symptoms, better social/occupational/global functioning, and a shorter duration of untreated psychosis; a poor premorbid/early onset subtype demonstrated greater negative and preoccupation symptoms, as well as greater psychosocial problems; and a long prodrome/late onset subtype was characterized by greater dysphoric symptoms.
conclusionsFindings indicate a need for further research with first-episode samples on the utility of subtyping based on early-course (premorbid, prodromal and onset-related) characteristics. Such efforts could enhance the parsing of heterogeneity, thereby advancing clinical practice and research.
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